ID A0A091CUQ2_FUKDA Unreviewed; 1516 AA.
AC A0A091CUQ2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Myosin-Va {ECO:0000313|EMBL:KFO21415.1};
GN ORFNames=H920_17209 {ECO:0000313|EMBL:KFO21415.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21415.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO21415.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO21415.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KN124379; KFO21415.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000023045; -.
DR eggNOG; KOG0160; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF273; UNCONVENTIONAL MYOSIN-VA; 1.
DR Pfam; PF00612; IQ; 6.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50096; IQ; 6.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 21..73
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 82..776
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 612..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..678
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1120..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 928..1118
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1168..1244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1333..1374
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1420..1447
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 612..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 176..183
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1516 AA; 176566 MW; AA2812EE0D1664D6 CRC64;
MEAGRGRQGV PAGPSGGRMV LKFARVWIPD PEEVWRSAEL LRDYRPGDKA LLLRLEEGKD
LEYRLDPKTK ELPHLRNPDI LVGENDLTAL SYLHEPAVLH NLRVRFIDSK LIYTYCGIVL
VAINPYEQLP IYGEDIINAY SGQNMGDMDP HIFAVAEEAY KQMARDERNQ SIIVSGESGA
GKTVSAKYAM RYFATVSGSA SEANVEEKVL ASNPIMESIG NAKTTRNDNS SRFGKYIEIG
FDKRYRIIGA NMRTYLLEKS RVVFQAEEER NYHIFYQLCA SAKSPEFKML RLGTADSFHY
TKQGGSPVIE GVDDAKEMAH TRQACSLLGI SESYQMGIFR ILAGILHLGN VGFTSRDSDS
CTIPPKHEPL SIFCDLMGVD YEEMCHWLCH RKLATAAETY IKPISKLQAT NARDALAKHI
YAKLFNWIVD HVNQALHSAV KQHSFIGVLD IYGFETFEIN SFEQFCINYA NEKLQQQFNM
HVFKLEQEEY MKEQIPWTLI DFYDNQPCIN LIESKLGILD LLDEECKMPK GTDDTWAQKL
YNTHLNKCAL FEKPRLSNKA FIIQHFADKV EYQCEGFLEK NKDTVFEEQI QVLKSSKFKM
LPELFQDDEK AISPTSAMSS GRTPLSRAPS KPTKGRPGQM AKEHKKTVGH QFRNSLHLLM
ETLNATTPHY VRCIKPNDFK FPFTFDEKRA VQQLRACGVL ETIRISAAGF PSRWTYQEFF
SRYRVLMKQK DVLGDRKQTC KNVLEKLILD KDKYQFGKTK IFFRAGQVAY LEKLRADKLR
AACIRIQKTI RGWLLRKKYL RMQRAAVTVQ RYVRGYQARC YVKFLRRTKA ATAVQKYWRM
YVIRRRYKMK QAATLVLQAY LRGYLARNRY HKMLREHKAV IIQKWVRGWL ARTRYSRCLH
AIIYLQCCFR RMMAKRELKK LKIEARSVER YKKLHIGMEN KIMQLQRKVD EQNKDYKCLM
EKLTSLEGTY NSETEKLRSD LERLQLSEEE AKVATGRVLS LQEELAKLRK DLEQTRSEKK
SIEERADKYK QETEQLVSNL KDENTLLKQE KESLNLLIVE QAKEMTETME KKLVEETKQL
ELDLNDERLR YQNLLNEFSR LEERYDDLKE EMTLMMNVSK PGHKRTDSTH SSNESEYTFS
SEIAETEDVP SRMEEPSEKK VPLDMSLFLK LQKRVTELEQ EKQVMQDELD RKEELVLRSK
AKEEERPQIR GAELEYESLK RQELESENKK LKNELNELRK ALSEKGAPEV TAPGAPAYRV
LMEQLTSVSE ELDVRKEEVL ILRSQLVSQK EAVQPKNTMT DSTILLEDVQ KLKDKGEIAQ
AYIGLKETNR LLESQLQSQK RSHENEAEAL RGEIQSLKEE NNRQQQLLAQ NLQLPPEARI
EASLQHEITR LTNENLYFEE LYADDPKKYQ SYRISLYRRL IDLMEQLEKQ DKTVRKLKKQ
LKVFAKKIGE LEVGQMENIS PGQIIDEPIR PVNIPRKEKD FQGMLEYKKE DEQKLVKNLI
LGKYSWCEGN SLPFRH
//
