ID A0A091CUW5_FUKDA Unreviewed; 2030 AA.
AC A0A091CUW5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Otoferlin {ECO:0000313|EMBL:KFO23364.1};
GN ORFNames=H920_15265 {ECO:0000313|EMBL:KFO23364.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO23364.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO23364.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO23364.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN123775; KFO23364.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000000350; -.
DR eggNOG; KOG1326; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF32; OTOFERLIN; 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1997..2017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..98
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 251..372
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 415..546
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 959..1084
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1131..1257
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1497..1626
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1747..1898
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 129..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..696
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2030 AA; 230364 MW; 6D42E8057D897E8E CRC64;
MALLVHLKTV SELRGKGDRI AKVTFRGQSF HSRVLENCEG VADFDETFRW PVASNVDRNE
MLEIQIFNYS KVFSNKLIGT FRMVLQEVVE ENRVEVTDTL TDDNNAILKT SLTVEVRYQA
ADGTVGSWDD GDFLGDESLR EEEKDSRETD GLLPGSRPSS RPPGEKSFRS KGREKTQRGR
DGEHKAGRSV FSAMKLGKNR PHKEEPQRQD EPAVLEMEDL DHLAIRLGDG LDPDSVSLAS
VTALTTNVSN KRSKPDIKME PSAGRPMDYQ VSITVIEARQ LVGLNMDPVV CVEVGEDKKY
TSMKESTNCP YYNEYFVFDF HASPDVMFDK IIRISVIHSK NLLRSGTLVG SFKMDVGTVY
SQPEHQFHHK WAILSDPDDI SAGLKGYVKC DVAVVGKGDN IKTPHKANET EEDDIEGNLL
LPEGLPAERQ WARFYVKIYR AEGLPRMNTS LMANVKKAFI GENKDLVDPY VQVFFAGQKG
KTSVQKSSYE PLWNEQVVFT DLFPPLCKRV KVQIRDSDKV NDVAIGTHFI DLRKISNDGD
KGFLPTLGPA WVNMYGSTRN YTLLDEHQDL NEGLGEGVSF RARLMLGLAV EILDTSNPEL
TSSTEVQVEQ ATPVSESCTG RVEEFFLFGA FLEASMIDRK NGDKPVTFEV TIGNYGNEVD
GLSRPQRPRP RKEPGDEEEV DLIQNSSDDE GDDDGDLASV SSTPPMRPQI TDRNYFHLPY
LECKPCIYIK SWWPDQRRRL YNANIMDHIA DKLEEGLNDV QEMIKTEKPY PERRLRGVLE
ELSNGCHRFL SLADKDQGHS SRTKLDRERL KSCMRELESM GQQAKGLRAQ VKRHTVRDKL
RQCQNFLQKL RFLADEPQHS IPDVFIWMMS NNKRIAYARV PSKDLLFSIV EEELGKDCAK
VKTLFLKLPG KRGFGSAGWT VQAKLELYLW LGLSKQRKDF LCGLPCGFEE VKAAQGLGLH
SFPPISLAYT KKQAFQLRAH MYQARSLFAA DSSGLSDPFA RVFFINQSQC TEVLNETLCP
TWDQMLVFDN LELYGEAHEL RDDPPIIVIE IYDQDSMGKA DFMGRTFAKP LVKMADEAYC
PPRFPPQLEY YQIYRGNATA GDLLAAFELL QIGPAGKADL PPINGPVDVD RGPIMPVPVG
IRPVLSKYRV EVLFWGLRDL KRVNLAQVDR PRVDIECAGK GVQSSLIHNY KKNPNFNTLV
KWFEVDLPEN ELLHPPLNIR VVDCRAFGRY TLVGSHAVSS LRRFIYRPPD RTAPTWNTTD
CRAFGRYTLV GSHAVSSLRR FIYRPPDRTA PTWNTTGEVV VSMEPEVPVK KLETMVKLDA
TSDAVVKVDV AEEEMEKKKK KKKGSAEEAE EEEPDESMLD WWSKYFASID TMKEQLRQQE
TSGADLEEKE EADYTEGLKG PMKGKEKARA AKEEKKRRTQ SPGPGQGSEV PEKKKPKIDE
LKVYPKELES EFDNFEDWLH TFNLLRGKTG DQEDGSAEEE RVVGRFKGSL CVYKVPLPED
VSREAGYDPT FGMFQGIPSN DPINVLVRVY VVRATDLHPA DINGKADPYI AIRLGKTDIR
DKENYISKQL NPVFGKSFDV EASFPMESML TVAVYDWDLV GTDDLIGETK IDLENRFYSK
HRATCGLAHT YSTHGYNIWR DPMKPSQILT RLCKDGKVDG PHFGPPGRVK VANRVFTGPS
EIEDENGQRK PTDEHVALSA LRHWEDIPRV GCRLVPEHVE TRPLLNPDKP GIEQGRLELW
VDMFPMDMPA PGTPLDISPR KPRKYELRVI VWNTDEVVLE DDDFFTGEKS SDIFVRGWLK
GQQEDKQDTD VHYHSLTGEG NFNWRYLFPF DYLAAEEKIV ISKKESMFSW DETEYKIPAR
LTLQIWDADH FSADDFLGAI ELDLNRFPRG AKTAKQCSME MATGEVDVPL VSIFKQKRVK
GWWPLLARNE NDEFELTGKV EAELHLLTAE EAEKNPVGLA RNEPDPLEKP NRPDTAFVWF
LNPLKSIKYL ICTRYKWLII KIVLALLGLL MLALFLYSLP GYMVKKLLGA
//
