ID A0A091CVN9_FUKDA Unreviewed; 741 AA.
AC A0A091CVN9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=2-5A-dependent ribonuclease {ECO:0000313|EMBL:KFO21820.1};
GN ORFNames=H920_16789 {ECO:0000313|EMBL:KFO21820.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21820.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO21820.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO21820.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN124295; KFO21820.1; -; Genomic_DNA.
DR RefSeq; XP_010606574.1; XM_010608272.2.
DR AlphaFoldDB; A0A091CVN9; -.
DR STRING; 885580.ENSFDAP00000008308; -.
DR GeneID; 104851118; -.
DR CTD; 6041; -.
DR eggNOG; KOG1027; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR OrthoDB; 2994922at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd10423; RNase_RNase-L; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR042745; RNase-L_RNase.
DR PANTHER; PTHR24141; 2-5A-DEPENDENT RIBONUCLEASE; 1.
DR PANTHER; PTHR24141:SF1; 2-5A-DEPENDENT RIBONUCLEASE; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT REPEAT 24..56
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 58..90
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 91..123
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 124..156
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 167..200
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 272..304
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 366..586
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 589..723
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 84901 MW; CC45CEDBC71085AD CRC64;
METKGPNNPQ ERPMPPHSRR ATMENNYSLI YAVKNKDVNQ IEQLLKIGAN VNFQEEEGGW
TPLHNAIQGG SKDIVDLLLD YGADPHQRKN NGATSFIIAG IEGNVELLRL FLSKGADVNE
YDSNGFTAFM EAAEHGNVEA LKFLYENGAN VNLHRETKDD QKLLGKGGGT ALMDAAKRGH
IDVLRILLEK MNAEVNACDN MGRSALIHGI QSSPDEKVKD ITCLLLDHGA DVCLRGEREK
TPLILAVERK HIGLVQLLLE QKHIEIDAKD GKGRTALLVA VNLNMKAIVK LLCKKGANTD
CGDLVWMAKR KHHDNDLAKL LCSYGARDYF QPPDEDWKPL SSRWGKDLKK LYRMYHRNTG
KLKIFKGEDY KIAKTSKGDV YLGFFEGQEV AVKVFREGSE HAEREMDCLR HIREHSNLLT
FYGSESDGVW LYVCIALCEE SLEEHLDKHR RDYMEDEEDT FARNVLASIF KAVQELHLHE
YIHQDLQPGN ILIDSKKAVL LADFDQSIKW TGDPQEIKSD LEALGWLALY VIKKGEIPFE
KLKARSNEQV LRLSPDEETK DLIHHLFFPG ENARDYLNNL LGHPFFWTWE NRYRTLRNVG
NENDIKVRNS DGDILKLLQP ESSECSRSFD KWKDKIDEFL MEKMDSFYKK SGNFYQNTVG
DLLKFIRNIG EHIDEEKNKW IKKIIGDPSH YFQKTFPDLV IYVYTKLQNT EYKKHFPQIY
NPSNLQCDQG IQNSRLAGSE C
//
