ID A0A091CZW2_FUKDA Unreviewed; 196 AA.
AC A0A091CZW2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Heat shock protein beta-8 {ECO:0000256|ARBA:ARBA00018965};
GN ORFNames=H920_14987 {ECO:0000313|EMBL:KFO23783.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO23783.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO23783.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO23783.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Displays temperature-dependent chaperone activity.
CC {ECO:0000256|ARBA:ARBA00003066}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000256|PROSITE-ProRule:PRU00285, ECO:0000256|RuleBase:RU003616}.
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DR EMBL; KN123755; KFO23783.1; -; Genomic_DNA.
DR RefSeq; XP_010602382.1; XM_010604080.2.
DR AlphaFoldDB; A0A091CZW2; -.
DR STRING; 885580.ENSFDAP00000021967; -.
DR Ensembl; ENSFDAT00000010536; ENSFDAP00000021967; ENSFDAG00000007322.
DR GeneID; 104848216; -.
DR CTD; 26353; -.
DR eggNOG; KOG3591; Eukaryota.
DR OMA; WPDWARS; -.
DR OrthoDB; 3089385at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0034620; P:cellular response to unfolded protein; IEA:InterPro.
DR CDD; cd06480; ACD_HspB8_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR043254; HSPB8.
DR InterPro; IPR042790; HspB8_ACD.
DR PANTHER; PTHR46906; HEAT SHOCK PROTEIN BETA-8; 1.
DR PANTHER; PTHR46906:SF1; HEAT SHOCK PROTEIN BETA-8; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Stress response {ECO:0000313|EMBL:KFO23783.1}.
FT DOMAIN 74..185
FT /note="SHSP"
FT /evidence="ECO:0000259|PROSITE:PS01031"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 21532 MW; 2EA4EA3655942857 CRC64;
MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLPSAW
PGTLRSGMVP RGPTAPARFG VPAEGRSPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE
VSGKHEEKQQ EGGIVSKNFT KKIQLPADVD PVTVFASLSP EGLLIIEAPQ VPPYAPFGES
GFNNELPQDS QEVTCT
//
