ID A0A091D1B8_FUKDA Unreviewed; 388 AA.
AC A0A091D1B8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Alkylated DNA repair protein alkB like protein 1 {ECO:0000313|EMBL:KFO24288.1};
GN ORFNames=H920_14418 {ECO:0000313|EMBL:KFO24288.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO24288.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO24288.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO24288.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
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DR EMBL; KN123629; KFO24288.1; -; Genomic_DNA.
DR RefSeq; XP_010643888.1; XM_010645586.2.
DR AlphaFoldDB; A0A091D1B8; -.
DR SMR; A0A091D1B8; -.
DR STRING; 885580.ENSFDAP00000011528; -.
DR Ensembl; ENSFDAT00000024249; ENSFDAP00000011528; ENSFDAG00000019064.
DR GeneID; 104877188; -.
DR CTD; 8846; -.
DR eggNOG; KOG2731; Eukaryota.
DR OMA; YKRRDPP; -.
DR OrthoDB; 47845at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR004574; Alkb.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR NCBIfam; TIGR00568; alkb; 1.
DR PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR PANTHER; PTHR16557:SF2; NUCLEIC ACID DIOXYGENASE ALKBH1; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 213..347
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT BINDING 231
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 233
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 287
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ SEQUENCE 388 AA; 43531 MW; 069F56B61A259055 CRC64;
MGKMAAAVSP VAILATEPGE DAFRKLFRFY RQSRPGTADL GGVIDFSAAH GGRSTGPGAQ
KVVRSQLSVS SVSEQDAHRA GLKPVSKWQA YGLKGYPGFI FIPNPFLPGY QWHWVKQCLK
LYSQKPNVCN LDKHMTKEEP RDLWEQSKEF LRYKEVNKRR PRSLLEKLRW VTLGYHYNWD
SKKYSADHYT PFPSDLAFLS EQVAAACGFQ GFRAEAGILN YYRLDSTLGI HVDRSELDHS
RPLLSFSFGQ SAIFLLGGLK RDEAPTAMFM HSGDIMVMSG SSRLLNHAVP RVLPNPEGEG
LPHCLETPLP AVLPHGAVVE PCSSEDWQVC ASYLRTARVN MTVRQVLATG QDFPLEPVEE
QKRDVTPDFC HLDDQNSHVK RARLNLDS
//
