ID A0A091D2C3_FUKDA Unreviewed; 354 AA.
AC A0A091D2C3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Vascular endothelial growth factor D {ECO:0000313|EMBL:KFO24345.1};
GN ORFNames=H920_14265 {ECO:0000313|EMBL:KFO24345.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO24345.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO24345.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO24345.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
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DR EMBL; KN123606; KFO24345.1; -; Genomic_DNA.
DR RefSeq; XP_010643482.1; XM_010645180.1.
DR AlphaFoldDB; A0A091D2C3; -.
DR STRING; 885580.ENSFDAP00000001198; -.
DR Ensembl; ENSFDAT00000015213; ENSFDAP00000001198; ENSFDAG00000011247.
DR GeneID; 104876939; -.
DR CTD; 2277; -.
DR eggNOG; ENOG502QVIH; Eukaryota.
DR OMA; FHTRTCA; -.
DR OrthoDB; 5307705at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IEA:UniProt.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR004153; CXCXC_repeat.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF11; VASCULAR ENDOTHELIAL GROWTH FACTOR D; 1.
DR Pfam; PF03128; CXCXC; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..354
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001872766"
FT DOMAIN 97..196
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 354 AA; 40261 MW; E99FF4C0C91DF07F CRC64;
MYREWAVVNI FMMAYVHLVQ GFGNEHGPVK QLSRSVIEWS EQQIRAASSL EELLRITHSE
DWKLWRCRLK LKSFTSMDSR SASHRSTRFA ATYYDIETLK VIDEEWQRTQ CIPRETCVEV
ASELGSTTNT FFKPPCVTVF RCGGCCNEEG LVCANTSTSY VSKQLFEISV PLTSVPKLVP
VKVANHTGCK CLPTAPRHSY SIIRRSIQIP EEDRCPHSKK LCPIDMLWDS NKCKCVLQDE
NPLAGTEDLS HLQEPALCGS HMKFDEDRCE CVCETPCPRD LIQHPENCSC FECKESLESC
CQKHKIFHPD TCSCEDRCPF HTKTCANGKP ACAKHCRFPK EKKAAQGLHS QENP
//
