ID A0A091D2H1_FUKDA Unreviewed; 467 AA.
AC A0A091D2H1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=H920_14213 {ECO:0000313|EMBL:KFO24405.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO24405.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO24405.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO24405.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN123586; KFO24405.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091D2H1; -.
DR STRING; 885580.ENSFDAP00000003988; -.
DR eggNOG; KOG0789; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14612; PTPc-N7; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR008356; Tyr_Pase_KIM-con.
DR PANTHER; PTHR46198; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR46198:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR01778; KIMPTPASE.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|EMBL:KFO24405.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 204..457
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 375..448
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 398
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
FT BINDING 364
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT BINDING 398..404
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT BINDING 442
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
SQ SEQUENCE 467 AA; 52360 MW; 3DAEB0FF88B98E57 CRC64;
MGGCGSLDLE ATPQAPGSRW SSSREDTTEV GPGVHPPNRI PARSSTTSRL CHICSGKMCP
VLGRESQGLK QQGLPRRALG WNQRRRNKWL RHTAWLSELL WASTHPSMVQ DCGGRSREQP
WASSLGAAMT QPVPTKAPAK KHVRLQERRG SNVALMLDVR SLGTVEPICS VNTPREVTLH
FLRTAGHPLT RWALQHQPPS PKQLEEEFLK IPSNFVSPED LDIPGHASKD RYKTILPNPQ
SRVCLGRAQS QEDGDYINAN YIRGYDGQEK VYIATQGPMP NTVSDFWEMV WQEDVCLIIM
LTQLRESKEK CVHYWPTEEE TYGPFRIRTQ DMKECPEYTV RQLSVQLQEK CRSVKHILFS
AWPDHQTPES AGPLLRLVAE VDESPETAIN SGPIVVHCSA GIGRTGCFIA TRIGCQQLKA
RAEVDILGIV CQLRLDRGGM IQTTEQYQFL HHTLALYAAQ LPQEPSP
//
