ID   A0A091D3G8_FUKDA        Unreviewed;       550 AA.
AC   A0A091D3G8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Interferon-inducible GTPase 1 {ECO:0000313|EMBL:KFO26634.1};
GN   ORFNames=H920_12033 {ECO:0000313|EMBL:KFO26634.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26634.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26634.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26634.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
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DR   EMBL; KN123144; KFO26634.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091D3G8; -.
DR   eggNOG; ENOG502QS9R; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   CDD; cd04104; p47_IIGP_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR030385; G_IRG_dom.
DR   InterPro; IPR007743; Immunity-related_GTPase-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR32341:SF16; GTP-BINDING PROTEIN; 1.
DR   PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR   Pfam; PF05049; IIGP; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51716; G_IRG; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT   DOMAIN          204..386
FT                   /note="IRG-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51716"
SQ   SEQUENCE   550 AA;  61114 MW;  048E6F29E51087F6 CRC64;
     MNLSFTIAQV VKIVRVIGGE SEDWVRSHRF IPSGLSLPRD ICSCVNSEVT VDFKKSCRSE
     PQITFYQGSR DVGSSGQRSV GLRRCAVDSS GHFLLSSSLL QGTHRTRSSP LRPVWTWGRD
     RPRKDLPSST AMDAFISAFL ENLSQGNFQQ LAADFASHYA TLVSKAGGIL PAETLGRLDE
     VFMEGNLQAV VNMIQEVFSA AESAVLEVAV IGESGTGKSS FINVLRGLGH DDEGAADVGV
     VETTMKKTPY QHPKYPNVTF WDLPGTGTPK FSPDTYLEKV GFASFDFFII VSSSRFSLHD
     ALLVQKIKAL GKKFYFVRTK VDSDLYNEQE AKPQSFKRER VLQHIRDYCL ANLSDIGVPD
     PRVFLVSNFD LHDFDFPSLE KTLLAELPAH KRQVFVLMLP TLSDETVELK RAVLRGKIWL
     EAVRSSASAF VPFAPLIKGF DVHEQEARLK LYRGYFGLDD ESLKEIAEKL GTSVQDIKGY
     TKCLDFWSLV EDDSAGAKAM SCVETFCSVN GGVPSVVFQF LKTRFLLWKF LDAVADDAKL
     LLHKIISAQV
//