ID   A0A091D6H3_FUKDA        Unreviewed;       790 AA.
AC   A0A091D6H3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Dynamin-binding protein {ECO:0000313|EMBL:KFO25860.1};
GN   ORFNames=H920_12778 {ECO:0000313|EMBL:KFO25860.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO25860.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO25860.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO25860.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN123330; KFO25860.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091D6H3; -.
DR   STRING; 885580.ENSFDAP00000007104; -.
DR   eggNOG; KOG3519; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd07589; BAR_DNMBP; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd12141; SH3_DNMBP_C2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR   PANTHER; PTHR22834:SF17; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          94..245
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          339..549
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          595..658
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          726..789
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          35..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          465..496
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        35..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   790 AA;  89611 MW;  D29E9B62C1525030 CRC64;
     MEPKDLPGKE NLGTKKKNLL FLRPRLYMLE RRKTDTAVEG AVSEDHAGVL RRSQSDRTEY
     SQKLQEKMSP QAEGPAAASP TPEEELQMGS MMAKRAEVIK ELIQTERDYA NDLELCLREV
     VRPLRDKEIE RLDVHSLFSN MESVHHLSAK LLSLLEEATA DVDPAMQVIG EVFLQIKGPL
     EDIYKIYCYQ HDEAQSLLES YEKEEELKQH WGPCLQSLKG RPALLDMGSL LIKPVQRLLK
     YPLLLWVAGR DGGLGLHPVS WVQEDGKHVH FVLSVDADLG NLEGSRALLC CVCSEMFSPS
     SLSVLKYKKN DEDESLKDKL SKLNIHSISK KSKRVTNHLK ILTRGDSQVK DNTFNKEEKL
     FRSLEKTVRQ CVKNISFCLQ DIQDALPFAL QRVTELQEMS QHPDQEELGS EETPRIAPDL
     CHDFAVQLQR HVLNPLSALL SLFPGPQKLI QKRYDKLLDY NSYLQQSERA ESDLAKKEYE
     ALNAQLVEEL QAFNQAAQTI LMNCLCSFVS LLRDLMLEAQ QGYATILPVP RLVSSLCEIQ
     NQILVKVQNL NFVKENSATF IERKLSFEKK KSVQTQPEVP RQTDTHRSQL LSTYSAEGLY
     QAKRKCNATQ EYDINLLEGE LVAVVEQKDP LGSTSRWLVD TGIVKGYVYS SFLRPYNPAK
     AQKAETENRL CDEDFDNISF FVCSRPGSDS VTGTPEGSIS DSSSSLSGTC GKFETKGSDI
     DSFQEVDEQI FYAVHAFQAR SNYELSLQEY QRVHILRFCD LSGNKEWWLA EAHGQQGYVP
     ANYLGKMTYA
//