ID A0A091D777_FUKDA Unreviewed; 555 AA.
AC A0A091D777;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Neutrophil cytosol factor 2 {ECO:0000313|EMBL:KFO26333.1};
GN ORFNames=H920_12275 {ECO:0000313|EMBL:KFO26333.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26333.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO26333.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO26333.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NCF2/NOXA1 family.
CC {ECO:0000256|ARBA:ARBA00008051}.
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DR EMBL; KN123200; KFO26333.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091D777; -.
DR STRING; 885580.ENSFDAP00000005050; -.
DR eggNOG; KOG4225; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR CDD; cd06406; PB1_P67; 1.
DR CDD; cd12046; SH3_p67phox_C; 1.
DR CDD; cd11871; SH3_p67phox_N; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR034889; NCF2_SH3.
DR InterPro; IPR035546; p67phox_SH3_1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034885; PB1_P67.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15175:SF3; NEUTROPHIL CYTOSOL FACTOR 2; 1.
DR PANTHER; PTHR15175; NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 100..133
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 269..328
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 380..458
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 486..545
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 333..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 62529 MW; C6B516A70084433B CRC64;
MSLAEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRLC FNIGCVHSIL ENMPEAEKTC
IIPALLPDSL SSSSLLTFSP ATTFSPQAFT RSINRDKHLA VAYFQRGMLY CQMEKYDLAI
KDLKEALTQL RGNQLIDYKI LGLQFKLFAC EVLYNIAFMY AKKEEWKKAE EQLALASSMK
SEPRHSKIDK AMESVWKQKL YEPVVIPVGR LFRPNERQVA QLARKDYLGK ATVVASVVDQ
DSFSGFAPLQ PQAAEPPPRP KTPEIFRALE GEAHRVLFGF VPETPEELQV MPGNIVFVLK
KGNDNWATVM FNGQKGLVPC NYLEPVELRI HPQQQPQEDM SLESDIPPPP NSNAPGRPQL
SPGQKQKEEP KEIQLKIPMS YTLKVHYKYT VVMETQPGLP YSHVRHMVSK KLELLPEHTK
LSYLPRDSNE LVTLSEESMQ DAWGQAKNYC LTLWCENTVG DQGFLEEPKE SEKSDFNRQT
KECQFKEGSR VVAIFSYEAT QPEDLEFLEG DGILVLSKVN EEWLEGECKG KVGIFPKAFV
EECAAADADS TPSTT
//
