ID A0A091D7U7_FUKDA Unreviewed; 1463 AA.
AC A0A091D7U7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=H920_12267 {ECO:0000313|EMBL:KFO26325.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26325.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO26325.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO26325.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; KN123200; KFO26325.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000001449; -.
DR eggNOG; KOG0921; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0033679; F:3'-5' DNA/RNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17972; DEXHc_DHX9; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044447; DHX9_DEXHc.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KFO26325.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 124..157
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 269..341
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 487..653
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 725..898
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 36..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1330..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1463 AA; 160704 MW; 3D4804A75EACBE47 CRC64;
MYFEVAYFWH ILDGSCKTFG YMKILQALDF DIQTGETNDT EERSGSPQRL QPRPLPRGAL
TPALAYYACV RTGSAPWNGG RSHFTAFSTR VVGASPQSLC GKPELRTDGQ ERVVLSGTGK
QGLVRVEGFN YTGMGNSTNK KDAQSNAARD FVNYLVRVNE VKSEEVPTVG IAPPPPPVTE
TTETAETGEN SESLPTSMGG PLPPHLALKA ENNSGVGASG FGAPGPTWDR GANLKDYYSR
KEEQEVEATL ESEEVDLNAG LHGNWTLENA KARLNQYFQK EKIQGEYKYT QVGPDHNRSF
IAEMTIYIKQ LGRRIFAREH GSNKKLAAQS CALSLVRQLY HLEVIEAYSG LTKKKEGERV
EPYRVNISPD LEHQLINVIQ ELNLEIIPPP VDPSMPVIFN TGKLAHFEPS QRQNQIGVVP
WSPPQSNWNP WTSCNIDEGP LAYATPEQIS MDLKNELMYQ LEHDQDLQAV LQERESLPVK
KFETEILEAI NQNSVVIIRG ATGCGKTTQV PQFILDDFIQ NDRAAECNIV VTQPRRISAV
SVAERVAYER GEEPGKSCGY SVRFESILPR PHASIMFCTV GVLLRKLEAG IRGISHVIVD
EIHERDINTD FLLVVLRDVV LAYPEVRIVL MSATIDTSMF CEYFFSCPII EVYGRTFPVQ
EYFLEDCIQM TQFVPPPKDK KKKDKEDDSG EDDDANCNLI CSDEYGPETK MSMSQLNEKE
TPFELIEALL KYIETLNVPG AVLVFLPGWN LICTMQKHLE MNPHFGSHRY QILPLHSQIP
REEQRKVFDP VPVGVTKVIL STNIAETSIT INDVVYVIDS CKQKVKLFTA HNNMTNYATV
WASKTNLEQR KGRAGRVRPG FCFHLCSRAR FERLETHMTP EMFRTPLHEI ALSIKLLRLG
GIGQFLAKAI EPPPLDAVIE AEHTLRELDA LDINDELTPL GRILAKLPIE PRFGKMMIMG
CIFYVGDAVC TIAAATCFPE PFISEGKRLG YIHRNFAGNR FSDHVALLSV FQAWDDARMG
GEEAEIRFCE HKRLNMATLR MTWEAKVQLK EILLNSGFPE ECLLTQVFTN TGPDNNLDVV
ISLLAFGVYP NVCYHKEKRK ILTTEGRNAL IHKSSVNCPF SSQDMKYPSP FFVFGEKIRT
RAISAKGMTL VTPLQLLLFA SKKVQSDGQI VFVDDWIRLQ ISHDAAACIT ALRAAMEALV
VEVTKQPNII SQLDPVNEHM LNMIRQISRP SAAGISLMIG AARYGDGPRP PKMARYDNGS
GYRRGSGYGG GGYGTGGYGS GYGGGHYGGG GYGGGGYGGG SNSYRRGYGG GYRGFRGGYR
GNFGGDYRGH SGDFRGPNGG DFRGPNGGDF RGPGGGDFRG PGGGDFRGPN GGDFRGPGGG
DFRGPDFRGP GGGDFRGPGG GDYRGPGGGD FRGPGGGDFR GPGGGDFRGP GGGGYRGSGG
FQRGGRGGFG SGYFGQGRGG GGY
//
