ID   A0A091D8W6_FUKDA        Unreviewed;      1021 AA.
AC   A0A091D8W6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Transcription factor E2F7 {ECO:0000256|ARBA:ARBA00039675};
GN   ORFNames=H920_11917 {ECO:0000313|EMBL:KFO26680.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26680.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO26680.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO26680.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR   EMBL; KN123114; KFO26680.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091D8W6; -.
DR   STRING; 885580.ENSFDAP00000008714; -.
DR   eggNOG; KOG2578; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR   PANTHER; PTHR12081:SF25; TRANSCRIPTION FACTOR E2F7; 1.
DR   Pfam; PF02319; E2F_TDP; 2.
DR   SMART; SM01372; E2F_TDP; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW   Nucleus {ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU003796}.
FT   DOMAIN          259..328
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   DOMAIN          399..484
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          674..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          788..809
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..1021
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..729
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1000..1014
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1021 AA;  111877 MW;  53F04F5BD5DFCF7C CRC64;
     MPSPSQQQQG PAESVAAATL PGSSEAKIQA WYHWITTAAS TLVGGGDRDP GWRRAGRVGT
     LSQPGRRGVP ASAGHSERGS GRLRCPRPAA DTCILFPRRR GAAEVPAEAK RLFGKAGMEV
     NCLTLKDLIN PKQARLELAI EDGENAQKEN IFVDRSRMAP KTPIKNEPID LSKQKIFTPE
     RNPITPVKLV DRQQTEPWTP TANLKMLISA ASPDIRDREK KKGLFRPIEN KDDVFTDSLQ
     LDIVGDSAVD EFEKQRPSRK QKSLGLLCQK FLARYPSYPL STEKTTISLD EVAVSLGVER
     RRIYDIVNVL ESLHLVSRVA KNQYGWHGRH SLPKTLRTLQ RLGEEQKYEE QMAHLQQKEL
     DLMDYKFGEH RKNGYPDSQD QQLLDFSEPD YSSSSANSRK DKSLRIMSQK FVMLFLVSKT
     KIVTLDVAAK ILIEESQDTP DHSKFKTKVR RLYDIANVLT SLALIKKVHV TEERGRKPAF
     KWIGPVDFSS SDDELVDVSA SVLPELKRET YGKIQVCARQ RLTRYGSFNT VQTSERMERK
     VISEPSSPYR KEQGSGGYSL EIGSLAAVYR QKIEDNSHES TSVSKRVVST AGSSETGFPV
     DSEYCVNPLA HQVFSVAQDL PTFSMQNSLN GQVGIPLAPV SSDVESMKPP LLAGQSLVYV
     PSTSLFMLCA SLREGPSPES GSEGDGRSSE IPATAELSLT PSSQKRLCED KKSWEEHEPA
     TKRQSRELED SPLSLVLPKK PSDSIEFAPG KSMGNRGSAS LEDTHVHGPH PAAEEVSGNA
     TANCFVSSEC ENPSRNTDTE KPSKGNESTK EASLLQYLYV QSPAGLNGFH ALLSGSQTPH
     SVGPPSGQLP SFSVPCMVLP SPTMGPFPVV YSPAMPVPIS SAPGTLPNTG PVNFSLPGLG
     SAAHLLISPA AMINPKSSTL PSADPQFQGQ PSLHLSPVMA RSHNVIQPES PVYIGHPASV
     VKLQQSPVPV TPKSMRRTHR ETFFKTPGSL GDPVLRSRER NQSRNTSSAQ RRLEIPSSGP
     D
//