ID A0A091DDM2_FUKDA Unreviewed; 495 AA.
AC A0A091DDM2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Nuclear receptor subfamily 5 group A member 2 {ECO:0000313|EMBL:KFO28598.1};
GN ORFNames=H920_09997 {ECO:0000313|EMBL:KFO28598.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO28598.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO28598.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO28598.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC subfamily. {ECO:0000256|ARBA:ARBA00007536}.
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DR EMBL; KN122715; KFO28598.1; -; Genomic_DNA.
DR RefSeq; XP_010633687.1; XM_010635385.1.
DR RefSeq; XP_010633688.1; XM_010635386.1.
DR RefSeq; XP_010633689.1; XM_010635387.1.
DR AlphaFoldDB; A0A091DDM2; -.
DR STRING; 885580.ENSFDAP00000022984; -.
DR GeneID; 104869989; -.
DR CTD; 2494; -.
DR eggNOG; KOG4218; Eukaryota.
DR OrthoDB; 2968690at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07167; NR_DBD_Lrh-1_like; 1.
DR CDD; cd07069; NR_LBD_Lrh-1; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5-like.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24086; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; 1.
DR PANTHER; PTHR24086:SF18; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 37..112
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 254..493
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT BINDING 375..378
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 470
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 474
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
SQ SEQUENCE 495 AA; 56363 MW; 3978EDB2EF0F9C07 CRC64;
MSSNSDTGDI RESLKHGLTP IVSQFKMVNY SYDEDLEELC PVCGDKVSGY HYGLLTCESC
KGFFKRTVQN NKRYTCIENQ NCQIDKTQRK RCPYCRFQKC LSVGMKLEAV RADRMRGGRN
KFGPMYKRDR ALKQQKKALI RANGLKLEAM SQVIQAMPSD LTISSAIQNI HSASKGLPLN
HAALPPTDYD RSPFVTSPIS MTMPPHGSLQ GYQTYGHFPS RAIKSEYPDP YTSSPESIMG
YSYMDGYQTS SPASIPHLIL ELLKCEPDEP QVQAKIMAYL QQEQANRSKH EKLSTFGLMC
KMADQTLFSI VEWARSSIFF RELKVDDQMK LLQNCWSELL ILDHIYRQVV HGKEGSIFLV
TGQQVDYSII ASQAGATLSN LMSHAQELVG KLRNLQLDQR EFVCLKFLVL FSLDVKNLEN
FQLVEGVQEQ VNTALLDYTL CNYPQQGDKF GQLLLRLPEI RAISMQAEEY LYYKHLNGDV
PYNNLLIEML HAKRA
//
