GenomeNet

Database: UniProt
Entry: A0A091DDR9_FUKDA
LinkDB: A0A091DDR9_FUKDA
Original site: A0A091DDR9_FUKDA 
ID   A0A091DDR9_FUKDA        Unreviewed;       486 AA.
AC   A0A091DDR9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-APR-2019, entry version 16.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   ORFNames=H920_09983 {ECO:0000313|EMBL:KFO28638.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO28638.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO28638.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO28638.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KN122714; KFO28638.1; -; Genomic_DNA.
DR   STRING; 885580.XP_010633681.1; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    486       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001871907.
FT   TRANSMEM    457    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   ACT_SITE    135    135       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    357    357       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     47    340       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    211    227       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    365    376       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    370    425       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    427    436       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   486 AA;  56023 MW;  F3245E54499B2E03 CRC64;
     MCGPWVAWFS VLLLFLTVAQ PVLKPAAPPV IKNQPFHIFW AAPTMHCKKS FKVGMNLEVF
     NIMTNPLETQ SGSTIAIFYP DELGYYPYIS QDGKSFNGGI PQSVNLSTHL TKTTADITRT
     LPWWQSEGLV IIDWENWKPQ WVRNWGNRMI YKNHSLAFTR YHHPDWLETK VKTVAQEEFE
     NAGRNFMNVT LTLALEMRPK YLWGFYLYPD CYNYDYRINP VFYTGNCPNE EVFLNDQLLW
     LWKKSTALYP SIYLDKILKS SLNALKFVHY RVREAMRIAE MARPDYVLPV FIFSRPFYLN
     SIETLSEEDF VHTIGESAAL GAAGMILWGE YEYISSKEAC LSVQQSIQRA LGPYAVNVTS
     AAKLCSQSLC GNHGRCVGKT PASPFYLHMP ESGSKKYTSN KSFRFVISEK SKLKTVMHMK
     DGFVCHCYYG WHGETCHHYS SDLLGWTNKA PTANFNLPVF LDIILSVILL NIFFIPYYKV
     NFSLKY
//
DBGET integrated database retrieval system