ID A0A091DE89_FUKDA Unreviewed; 5001 AA.
AC A0A091DE89;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Hemicentin-1 {ECO:0000313|EMBL:KFO28580.1};
GN ORFNames=H920_10026 {ECO:0000313|EMBL:KFO28580.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO28580.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO28580.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO28580.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KN122728; KFO28580.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000002949; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 8.
DR CDD; cd00096; Ig; 7.
DR CDD; cd00255; nidG2; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 39.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF28; HEMICENTIN-2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF07679; I-set; 31.
DR Pfam; PF13927; Ig_3; 7.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00409; IG; 39.
DR SMART; SM00408; IGc2; 39.
DR SMART; SM00406; IGv; 12.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS50835; IG_LIKE; 39.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 311..397
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 400..487
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 492..578
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 583..677
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 682..766
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 773..865
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 869..958
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 963..1052
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1057..1145
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1149..1235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1244..1332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1337..1425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1430..1517
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1522..1608
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1613..1703
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1708..1797
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1802..1891
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1896..1984
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1989..2080
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2084..2186
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2189..2287
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2292..2382
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2387..2474
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2479..2569
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2574..2651
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2668..2756
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2763..2852
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2857..2939
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2950..3038
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3043..3131
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3136..3220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3227..3315
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3320..3404
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3411..3497
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3502..3583
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3592..3678
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3683..3756
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3771..3858
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3863..3936
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4237..4459
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 4473..4512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4558..4595
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4638..4673
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4681..4721
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4798..4837
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 4477..4487
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4562..4572
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4802..4812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 5001 AA; 543870 MW; 691169EC7922089F CRC64;
MSIGAIKIAL EISLPGSFIY VFTDARSKDY RLAQEVLQLI QQKQSQVVFV LTGDCDDRNH
IGYKVYEEIA ATSSGQVFHL DKKQVNEVLK WVEEAVQASK VHLLSTDHLE RAVNTWKIPF
DPSLKEVTVS LSGPSPVIEI HNPLGKLIKK GFGLNELLNI HNSAKVLNVK EPEAGMWTVK
TSSSGRHSVR ITGLSTIDFR AGFSRKPTLD FKKTVNRPVQ GTPTYVLLNT SGISSPGKVD
HLELLSISGS SLKTIPVKYY PDRRPYGIWN ISEFIPPNEA FFLKVTGYDK DDYLFQRVSS
VSFSSIVPDA PRVTMPMKTP GYYLQPGHIP CSVESLLPFT LSFLRNGVTL GVDQYLKESA
SVNWDIENVT LSDEGSYECI AVSRAGTGRA QTYFDVSEPP PVIQVPDNVT VAPGERAVLT
CLVISAVDYN LTWQKNGRDV RLAEPARIRT LANLSLELRS VKVSDAGAYH CMASSEGGSA
AVPVFLTVQV LPTIQHGQQI LSTIEGIPIM LPCKASGIPK PSIVWTKKGE LIPTGSPKFS
AAADGSLYVV SPGGEQSGEY VCTATNAAGY AKRKVQLTVY VRPRIFGEHL GLTQDKPVEI
SVLAGEEVTL PCEVKSLPPP IITWAKEAQL ISPLSPRHMF LPSGSMKITE TRISDSGMYL
CVATNIAGNV TQSVKLSVYV PPKLQHGPKH VKVQVSHRVD IPCNAQGSPP PVITWSKGGQ
TILADGEQHI IHPGGTLTIS QAMLSDAGIY SCVATNIAGS DEAEITLQVQ EPPTMEDLEP
PFNTPFQERL ASQHIAFPCP AKGAPKPTIK WLHNGGELTG REPGISILEN GTLLVIASVT
LYDNGEYICV AVNEAGTTER KYNLRVHVPP VIKDEEHLTN VSVLVNQLTS LFCEVEGTPS
PIIQWYKDDV QVTESSTIQI LNNGKILKLF KVTTEDAGRY SCKAINIAGS AQKHFSIDVL
VPPSIIGASS PNEVFAIINH STSLECQVKG SPFPTIHWFK DGKPLFLGDP NIELLDRRQI
LHLKNARRSD KGRYQCAVSN AAGKQAKDMK LTIYIPPSIK GGNATTEVSA LINSLIKLEC
EARGLPVPAI TWYKDGQLVL SSSQALYIDK GQFLHIPRAQ VSDSATYTCH IASVAGTSEK
SFHVEVYVPP MIEGDSATPL NKQVVIAHSL SLECKAAGSP PPSLTWLKDG APVKTSDNIR
IEAGGKKLEI MSALEVDQGQ YVCVATSVAG EKEIKYEVDV LVPPTIKSLG LSERAVVKYK
PVTLQCIANG IPNPSITWLK DDQPVNTAQG NLKIQSSGRV LQIAKALLED AGRYTCVATN
AAGETQQHTQ LHVHEPPSLE DAGRMLNETV VVNNPIQLEC KAAGNPLPVI SWYKDSHPLS
SSTSVTFLNR GQIIDIESAQ ISDAGVYKCV AINSAGATEL FYSLQVHVPP SISGSNNMIT
VVVNNPVRLE CEARGIPAPS LTWLKDGSPV SSFANGIQIL SGGRILALTS AQISDSGRYT
CVAVNAAGEK QRDVDLSVYV PPNIMGEEQN ISVLISQPVD LLCQSDAVPP PTLTWLKDGR
PLLKKPGLSI SENGSVLKIE DTQVQDTGRY TCEATNIAGK TEKNYNVNIW VPPSIYGSDE
LVQLIVTEGN LITLVCESSG IPPPNLIWKK KGSPVLADSV GRVRMLSGGR QLQISVAKKA
DAGLYTCVAS NVAGTTKKDY NLQVYIRPII TNSGSHPTEI VATRGKTVSL ECEVQGMPKP
TVTWMKDGRP LTKGRGAELL DDGHILQLKN ILVSDTGRYV CVAMNVAGMS DKKYDLNVHV
SPSIVGNHGT PENISVVEKN SVSLTCEASG IPLPSITWLK DGWPVSLSST LRILAGGRTL
RLIQARIEDA GQYTCIVRNT AGEERKLFGL SVLEPPRIVG ENTPEDVKVK EKQSVTLTCE
VTGNPVPEIT WHKDGQLLQE DETHRIMSGG HFLQITNAQV SHTGRYVCLV SNIAGEKSKS
FSLNVFVSPT ILGVGSDGSP EDVIVTLNSP TSLVCEAYSY PPATITWFKD GAPLESTQNI
RILPGGRTLQ ILNAQESNAG RYSCVATNEA GEMIKHYEVK VYIPPIINKG DILGPGLSPK
EVKIKVNHTL TLECEAHAIP SASLSWYKDG QASQLFLFSK DDHVTIAANG HTLQIKEAQI
SDTGRYTCIA SNLAGEDELD FDVNIQVPPS FQKLWEIGNM LDTGRSGEAK DVIINNPISL
FCETNAAPPP TLTWYKDSHP LTSSDKVMIL PGGRVLQIPR AKVEDAGRYT CVAVNEAGED
SLQYDVRVLL PPVIKGAPGE LPEEVTVLVN KGALLDCSSS GSPTPRNSWQ KDGKPLLEDE
HRKFVSNGRM LQIVNAQIID VGRYVCIAEN SAGSAKKYFN LNVHVPPSVV GPNPENLTVV
VNNFISLTCE VSGFPPPDLS WLKNEQPIKP NTNALIVPGG RTLQIIRAKV SDGGEYTCIA
INQAGEKRKK VFLTVYVPPS IKDHGSESLS VVNVREGTSV SLECESNAVP PPVITWYKNG
RIITESTHVE ILADEQMLHI KKAEVSDTGQ YVCRAINVAG RDDKNFHLNV YVLPSIEGPE
REVVVETTSN PVTLTCDATG IPPPMITWLK NHRLMEYSDS LEVHILSGGS KLQIARSQHS
DSGNYTCIAS NIEGKAQKNY ILLIQVPPSV SGAETPSEVS VLLGEDVELI CDANGIPVPV
IRWLRDGKSI TNGETENIQV TANGSTLNVY GAHTSDRGKY MCVATNPAGE DDRIFNLNVY
VPPKIRGNKE EAEKLVALVD TSLNIECRAT GTPPPQINWL KNGLPLPLSS HVRLLSAGQV
IRIVRAQVSD VAVYTCVASN RAGVDNKHYS LHVFVPPHMD NAMGTEEITV VKGSSTSMTC
VTEGTPTPRM SWLRDGQPLG LDAHVVISSQ GMVLQLIQAV TEDSGRYTCM ASNDAGEVSK
HFILKVLEPP HINGSEESGE ISVIVNNPLE LTCIASGIPA PKITWMKDGR PLLHTDQVQS
LRGNSVLQIS SAQVEDTGRY TCLASSPAGD DDKEYLVRVH VPPNIAGTEE PQDVTVLQNR
QVTLECKSDA VPPPVIMWLR NGDQLQATPR VRILSAGRYL QINNADLGDT ANYTCVASNV
AGKTTREFIL TVNVPPNIKN GPQNLVILMN KSIILECLAE GVPTPRITWR KDGAVLAGNH
ARHSILQNGF LHIQSVHVAD SGRYLCMATN AAGTDRRRID LQVHVPPSIV PGPTNITVTV
NVQTTLACEA SGVPKPSVSW RKNGHLLNVD QNQNSYRLLS SGSLVIISPS VDDTATYECT
VTNDAGKDKR TMDLTVQVPP TIADEPTDFL VTKQSPAVIT CTALGVPFPS IHWTKNGIRL
LPRGDGYRIL SSGAIEIFAT QLNHAGRYTC VARNAAGSAH RHVTLFVQDP PVIQPQPSEV
DVIVNNPILL PCEATGTPSP FISWQKEGIN VITSGKSHAA LPSGSLQISR AAREDAGTYT
CVAQNSAGTA LGKIKLTVQA PPVINTHPKE YAVAVDKPIM LPCEADGLPP PDITWHKDGH
VIMESIRQRI LNSGALQIAF AQPDDTGQYT CVAANVAGSS SISTKLIVHI PPRIRSTEAH
YAVNENTQAV LPCVADGIPT PAINWKKNNV LLTNLLGKYT AEPYGELILE NVVLEDSGTY
TCIANNAAGE DTHTVSLTVN VLPTFTELPG DVSLNKGEQL RLSCKATGIP LPKLTWTFNN
NIIPAHFDSV SGHSELVIEK VSKVDSGTYV CTAENSVGFV KAIGFVYVKE PPVFKRDYPS
NWIEPLGGNA ILNCEVKGDP VPTIQWSRKG VDIEISHRIR QLGNGSLAIY GTVNEDAGDY
TCVATNEAGV VERSMSLTLQ SPPVIALEPV ETIVDAGGKV RLDCQATGEP QPMVTWSRQG
HSVPWDARVS VLPNNSLYIA AARKEDTSEY ECVARNLMGS VLVRVPVIVR VDGHWSEWSP
WEECSKSCGR GNRTRTRTCN NPLAQHGGRP CEGNAVEIIM CNMRPCPVHG AWSPWQPWGG
CSKSCGEGTQ MRTRLCNNPP PSFDGSYCSG AETQMQVCRE RPCPVDGRWA PWASWSACTV
SCGGGTRQRT RDCSDPVPQY GGRKCEGSDI QSDFCNNDPC PTHGNWSPWS AWGTCSRTCS
GGQMRRYRTC DDPRPFHGGR ACAGPDTQLQ RCNTDRCPVD GGWGNWQSWS HCSVSCGGGE
KTRKRLCDNP VPSKGGRSCR GDATQVSRCS TQACPGGPHR ARGSVIGNIN DVEFGIAFLN
ATVTDSPNSD TKIIRAKITN VPRSLGPAMR KIVSILNPIY WTTAKEIGEA VNGFSLTNAI
FKRETQVEFA TGEILRMTHI ARGLDSDGVL LLDIVVSGYV LQLLSPAEVN VKDYTEDYIQ
TGPGQLYAYS TRLFTVDGIS VPYTWNHTVF YDEAQGRMPF LVETLHASSV ESDYNQLEET
LGFQIHASIS KGDRSNQCPS GFTLDSVGPF CVDEDECTAG NPCSHTCHNA MGAYYCSCPS
GLTIAADGRT CQDIDECALG GHTCHTGQDC DNTIGSYRCV VRCGMGFRRT SDGLSCQDIN
ECQESSPCHQ RCFNIVGSFH CGCEPGYQLK GRKCIDVNEC RKDVCRPDQH CKNTRGGYKC
IDLCPNGMTK AENGTCTDID ECKDGTHQCR YNQLCENTRG SYRCVCPRGY RSQGLGRPCL
DINECEQVPK PCAHQCSNTP GSFKCVCPPG QHLLGDGKSC AGLERLPHYG TQYSSYNLAR
FSPVRHNRQP QQHYRQYSHL YSSYSEYRNS RTSFSRTRRT IRKTCPEGSE ASHDTCVDID
ECQHRDTCQH ECQNTIGSYQ CICPPGYQLT LNGKTCQDVD ECLEQNVRCG LNRMCFNMRG
SYQCIDTPCP PNYQRDPVLG FCLKNCPPND LECALSPYAL EYKFVSLPFG IAANQDLIRL
VAYTQDGVMH PRTTFLMVDK EQTVPFALRD ENLKGIVYTT RALREPDTYR MRVRASSYSA
NGTIEYQTTF LVYIAVSAYP Y
//
