ID A0A091DEJ4_FUKDA Unreviewed; 4184 AA.
AC A0A091DEJ4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=H920_07947 {ECO:0000313|EMBL:KFO30569.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30569.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO30569.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO30569.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR EMBL; KN122397; KFO30569.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000000236; -.
DR eggNOG; KOG0891; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 2.
DR Pfam; PF20502; DNAPKcs_CC1-2; 2.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFO30569.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2915..3594
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3777..4109
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4152..4184
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2057..2076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2619..2641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2694..2723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3210..3230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4184 AA; 476441 MW; ABE3EDC08823F739 CRC64;
MADSRSSVRG SLLQLQEFLS TADHYSAATS SYQLIRGLGQ ECVLSTSSAV LGGYRPELCG
PLTLRVRLES ASPVFFPSYV EFEVSRIFVE EYKKTILFPP IIRREFRDCR EEALKFLCIF
LEKIGQKIVP YSLDIKLLQT LRSSRVMDEF KVGELFNKFY GELALKTKVS DTVLEKVYEL
LGVLGEVHPS EMINYSENLF RAFLGELKTQ MTSAVREPKL PVVAGCLKGL TSLLCNFTKS
MEEDPQTSRE IFDFALKAIC PQISYMVAKD AEAHKSKLQY FMEQFYGIIR SIDSNSKELS
IAIRGYGLFA EPCKVLNAKD VDFMYVELIQ RCKQMFLTET DTVDDHVYQM PSFLQSIASV
LLYLDTVPEV YTPVLEHLMV VQIDSFPQYS PKMQSVCCKA IVKVFLALAE KGPLLWNCIG
TVVHQGLIRI CSKPVVLQKG ADSESEHQRA SGEVRTGKWK VPTYKDYVDL FRQLLSCDQM
MDFVLADETF LFVNSSLQSL NRLLYDEFVK SVLKIVEKLD LTLEKQTGEQ EDGNEATGIW
VIPTSDPAAN LHPARPKDFS AFINLVEFCR EILPEKQVRF FEPWVYSFSY ELILQSTRLP
LISGFYKLLA IGVRNAKKMK YFEGVSSKSL KHCPEDPEKY SCFALVAKFG KEVSVKMKQY
KDELLASCLT FVLSLPHDII ELDMKAYVPA LQMAFKLGLS YTPLAEVGLS ALKEWSLHIH
KNVIQPYYKD ILPCLNGYLK TSTLSDETKN IWEVSALSQA AQKGFSNVVL KHLKKTKNLP
SNEAVSLEEI RIRVVQMLGS LGGQINKNLV TAASSDEMMK KCVAWDREKR LRFAVPFREM
KPIIYLDVFL PRVTELALST SDRQTKVAAC ELLHSIVMFM LGKATQIPEG GEGLPPLYQL
YKHTFPVLLR LACDVDQVTR QLYEPLVMQL IHWFTNNKKF ESQDTVALLE AILDGIVDPV
DSTLRDFCGQ CIREFLKWSI KQTTPQQQEK SPVNTKSLFK RLYSFALHPN AFKRLGASLA
FNNIYREFRF GRKYSATDDQ GFGCCGQVRV TSSISDIVES FVLGEPQLDF FLKLPADSYM
ENGSEWDRME REEESLVEQF VFEALVIYME SLALAHTDEK SLGTVQQCCD VIDHLRRIIE
KKHASLNKAK KRRLPRGFPP STSLCLLDLV RWLLAHCGRP QTECRHKSIE LFYKFVPLLP
GNKSPSLWLK DVIKKEDISF LINTFEGGGS SCNRLSGILA QPTLFHLEGP FSLRAALQWL
DLLLAALECY NTFIEEKTVE AHEVLGTKAY SSLWKSVAFF LESIAMNDIT AAEKCFGTGA
AGSQPSPHEE ERYNYSKCTV VVRIMEFTAT VLNTSPEGWK LLEKDLCNTN LMKIVVRTVC
EPVNIGFNIS DVQVMDHLPS VCVNLMKALK KSPYKDILET HLRENITAQS VEELCAVDLY
GPDAHLERTK LASVVSACKQ LHRAGFLHVV SLSQSPALHH SIGMRLLSLV YEGIAPGEER
QCLLSLDPSC KRLANGLLEL AFAFGGLCEH LVSLLLNATL LSTPSSHSSQ RSIISFSHGE
YFYSLFSETI NAELLKNLDL VVSELMKSSM DNPKMVSTIL NGMLDQSFRD RTTQKHRGLK
LVTIILQNWR KCDSWWSKDS TSENKMAVLA LLAKILQIDS SVSLNINHSS FPEVFATYAS
LLADSKLGLH LKGQAVILLP FFTSLTGGYL EDLKGVLENL IVSNFPMKSD EFPPGTLRYN
NYVDCMKKFL GALELSQSPI LLQLMTEILC REQQHVMEEL FQTTFKRIAS RSLCATQSDL
LESVYKMFRR NDLLSNKTRQ AFVDRCLLTL LWHCSLDALR EFFSKIMVDA IDTLKSRFTK
LNESTFDTQI TKKMGYYKML EVMYSRLSKD DVHSKESKIN QVFHGSCVTE GNELTKTLVK
LCHDAFTENM AGENQLLERR RLYHCAAYNC AISVICCVFN ELKFYQGFLF SEKPEKNLLI
FENLIDLNRC YVFPIEVEVP MERKKKYIEI RKEAREAANE DSDGPHYMSS LSYMANSSLS
EEMSQFDFST GVQSYSYNSQ DPKSTTGHFQ RQESHDPKIQ DDVLELEMDE LNQHECMATM
TALIKHMQRN LSCPKGEESS MPKDLPSWMK FLHDKLGNLS VPLNIRLFLA KLIINAEEVF
RPYAKHWLGP LLQLAVSENN GGEGIHYMVV EIVATVLSWT GVATPTGVPK DEVLANRLLY
FLMKHVFHPK RAVFRHNLEI IKTLVECWKD CLSIPYRLIF ERFSSQDPNS KDNSVGIQLL
GIVMANSLPP CDPKCGIEST KYFQALVNNM SFVKYKEVYA AAAEVLGLIL QYITKKKNIL
EESVCELVVK QLRQHQNTRE DKFIVCLNKA VKGFPPLADR FLNSVFFLLP KLHGVMKTLC
LEVILCRAEE IPELYLQLKS KDFIQVMRHR DDERQKVCLD IIYKMMAKLK PVELQELLNP
IVEFISHPSP MCREQMYNIL MWIYDNYRDP ESQKDDDSQE IFRLAKDVLI QGLIDENLGL
QLIIRNFWSH ETRLPSNILD RLLALNSLYS PKIEGHFLSL ATNFLLEMTS MSPDYPNLMF
EHPLSECEFQ ECTIDPDWRF RSTILTPMFV ETQASPSTLQ THSLDDSFPA QGPKSGQVRA
TQQQYDFTPT QTAEGRSSFN WLTGSSIDPL ADYTMPSLSS DSLSSSLLFA HKRSEKSQRV
PSKSVGPNFG EKRLSLPGDE VDNKVKDTDN RAEILRLRRR FLKNQEKLSL IYAKKGIVEQ
KREKEIKSEL KMKQDAHIIL YRSYRHGDLP DIQIQYSSLI TPLQAVAQRD PLIAKQLFSS
LFSGILKEMD RFKTVSEKNN ITHKLLQDFN HFLSTTFLFF PPFVSCIQEI SCQHPDLLSL
DPASVRTGSL ASLQQPGGIR LLEEALLHLA PAELPAKRVR GKTCLPPDTL RWMELAKLYR
SIGEYDVLRG IFSNEIGTKQ VTQNALLAEA RSDYSEAARQ YNEALNKQEW VDGEPSEAEK
DFWELASLDC YNHLSEWKSL EYCSTASVDS ESPPDLSKMW NEPFYQETYL PYMIRSKLKL
LLRGEGNQSL LSFMDEAMRR ELQQALTELQ YSQELSLLYI LQDDLDRAKY YVDKGIQIFI
QNYSSIDVLL HRSRLIKLQS VQALTEIQEF ISFISKQGNL SSQVSLKRLL KTWTNRYPDA
KMDPMNIWDD IITNRCFFLS KIEEKLSPLS DDSMSVDEDE GHSDRRDGDE LEEGVTSLIQ
SCRFSMKMKM TESAWQQNNF SLAMKLLKEM HKESKTRADW QVQWVQSYCR LSHCRSRAQR
PPEQILTVLK TVSLLADENA TSSYLNKNIL ASCDQNILLG TTFRIMADAL SSDPALLADM
EGSKARQILE LSGSSTDSAE RVIVGLYQRA FLHLSKAVQA VEGEAQPSCW SYGPVAGVTD
AYMTLVDFCD EQLRKAEEHA SGESKKEETI VNSAELKVYP ALVVEKMLKA LKLNSTDARL
KFPRLLQIVE QYPEETLSLM TKELLLSPER PSEFQMTSPI LVSPVPAGST ISSGVQDLLS
GISSIPCWQF IGWISHMVAL LDKEEASAVQ HTVEEIAENY PQAIVYPFII SSESYSFKDT
SAGHKNKEFV ARIKSKLDQG EVIQDFINAL EQLSNPDLLF KDWVADIKDE LGKNPVNKRN
IEKLYGKMYA ALGNPQAPGL GPFRRRFIQA FGKEFDKHFG NGGSKLSKMK LGDFSDITDE
LLSKMKNYSE PPGNLKECSP WMSEFKVEFL RNELEIPGQY HGRGKPLPEY HARISGFDER
IKVMNSIRRP KHIVIRGHNE REYPFLVKGG EDLRQDQRIE QLFEIMNVIL SRDAACSQRN
MQLRTYCVVP MTSRLGLIEW IENTFTLKDI LLNNMSQEEK AAYLSNDIRA PIIDYKEWLA
KMSGKYDAAA YVLMYKGANR TETVMAFRKR ESKVPADLLK RAFVKMSTGP EAFLALRSHF
STSHALLCIS HWLLGIGDRH LNNFMVTMET GGIIGIDFGH AFGSATQFLP VPELMPFRLT
RQFINLMLPM KETGLVYSVM VHALRAFRSD ADLLTSTMDV FIREPSFDWK NFEQKMLKKG
GSWIQKVNVT DQNWYPRQKI CYAKRKLAGA NPAVITCDEL FLGHEKSPAF GSYTAVARGS
RDHNIRAREP ESGLSEETQV KCLLDQATDP NILGRAWRGW EPWL
//
