ID A0A091DFU4_FUKDA Unreviewed; 534 AA.
AC A0A091DFU4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC3 {ECO:0000256|RuleBase:RU367076};
DE Short=RNA polymerase III subunit C3 {ECO:0000256|RuleBase:RU367076};
GN ORFNames=H920_07574 {ECO:0000313|EMBL:KFO31024.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31024.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31024.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31024.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific core component of RNA polymerase III which synthesizes small
CC RNAs, such as 5S rRNA and tRNAs. {ECO:0000256|RuleBase:RU367076}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000256|RuleBase:RU367076}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367076}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase
CC subunit family. {ECO:0000256|ARBA:ARBA00007206,
CC ECO:0000256|RuleBase:RU367076}.
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DR EMBL; KN122330; KFO31024.1; -; Genomic_DNA.
DR RefSeq; XP_010627803.1; XM_010629501.2.
DR RefSeq; XP_010627804.1; XM_010629502.2.
DR AlphaFoldDB; A0A091DFU4; -.
DR STRING; 885580.ENSFDAP00000022762; -.
DR Ensembl; ENSFDAT00000009536; ENSFDAP00000022762; ENSFDAG00000021078.
DR GeneID; 104865789; -.
DR CTD; 10623; -.
DR eggNOG; KOG2587; Eukaryota.
DR OMA; QHNLLWH; -.
DR OrthoDB; 2875034at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.140.1450; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 4.
DR InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR InterPro; IPR039748; RPC3.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR12949:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3; 1.
DR PANTHER; PTHR12949; RNA POLYMERASE III DNA DIRECTED -RELATED; 1.
DR Pfam; PF08221; HTH_9; 1.
DR Pfam; PF05645; RNA_pol_Rpc82; 1.
DR Pfam; PF20912; RPC3_helical; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU367076}; Nucleus {ECO:0000256|RuleBase:RU367076};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367076}.
FT DOMAIN 7..66
FT /note="RNA polymerase III subunit RPC82-related helix-turn-
FT helix"
FT /evidence="ECO:0000259|Pfam:PF08221"
FT DOMAIN 146..345
FT /note="RNA polymerase III Rpc82 C -terminal"
FT /evidence="ECO:0000259|Pfam:PF05645"
FT REGION 197..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 60685 MW; 3240DE431BE861EA CRC64;
MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIV HDTGTSLDQV KKALCVLIQH
NLVMYQVHKR GVVEYEAHCS RVLRMLRYPR YIYTTKALYG DTGELIIEEL LLNGKMTMSA
VVKKVADRLT ETVEDGKTMD YAEVSNTFMQ LADTRFVQRC PMVHTPENSD TGPPPPAPNL
VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKH PTDNKEPIPD DGIYWQANLD
RFHQHFRDQA IVSAVANRMD QTSSEIVRAM LRMSEVTTSS DAPFTQPLSS NEIFRSLPVG
YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINFCK ALASLATATL ESVIQERFGS
RCARIFRLVL QKKHLEQKQV EDFAMIPAKE AKDMLYKMLS ENFISLQEIP KTPDHAPSRT
FYLYTVNILS AARMLLHRCY KSVTNLIERR QFETKENKRL LEKSQRVEAI IASVQATGAE
EAQLQEIEEM ITAPERQQLE TLKRNVNKLD ASEIQVDETI FLLESYIEST MKRQ
//
