ID   A0A091DGI9_FUKDA        Unreviewed;       963 AA.
AC   A0A091DGI9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Cleavage and polyadenylation specificity factor subunit 3 {ECO:0000313|EMBL:KFO31214.1};
GN   ORFNames=H920_07405 {ECO:0000313|EMBL:KFO31214.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31214.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO31214.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO31214.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KN122310; KFO31214.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091DGI9; -.
DR   STRING; 885580.ENSFDAP00000004781; -.
DR   eggNOG; KOG1137; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd16292; CPSF3-like_MBL-fold; 1.
DR   CDD; cd01838; Isoamyl_acetate_hydrolase_like; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 2.
DR   Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR021718; CPSF73-100_C.
DR   InterPro; IPR001087; GDSL.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF11; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF11718; CPSF73-100_C; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF00657; Lipase_GDSL; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM01098; CPSF73-100_C; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT   DOMAIN          24..234
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          246..396
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
FT   DOMAIN          506..712
FT                   /note="Pre-mRNA 3'-end-processing endonuclease
FT                   polyadenylation factor C-term"
FT                   /evidence="ECO:0000259|SMART:SM01098"
SQ   SEQUENCE   963 AA;  108182 MW;  54ACDE5E446811B7 CRC64;
     MSAIPAEESD QLLIRPLGAG QEVGRSCIIL EFKGRKIMLD CGIHPGLEGM DALPYIDLID
     PAEIDLLLIS HFHLDHCGAL PWFLQKTSFK GRTFMTHATK AIYRWLLSDY VKVSNISADD
     MLYTETDLEE SMDKIETINF HEVKEVAGIK FWCYHAGHVL GAAMFMIEIA GVKLLYTGDF
     SRQEDRHLMA AEIPNIKPDI LIIESTYGTH IHEKREEREA RFCNTVHDIV NRGGRGLIPV
     FALGRAQELL LILGDVRALE ELSQRSRLGS FIEKRGLVPA ALHEYWQNHP ELHDIPIYYA
     SSLAKKCMAV YQTYVHAMND KIRKQININN PFVFKHISNL KSMDHFDDIG PSVVMASPGM
     MQSGLSRELF ESWCTDKRNG VIIAGYCVEG TLAKHIMSEP EEIATMSGQK LPLKMSVDYI
     SFSAHTDYQQ TSEFIRALKP PHVILVHGEQ NEMARLKAAL IREYEDNDEV HIEVHNPRNT
     EAVTLNFRGE KLAKVMGFLA DKKPEQGQRV SGILVKRNFN YHILSPCDLS NYTDLAMSTV
     RQTQAIPYTG PFHLLSYQLR KLTGDVEELE IQEKPALKVF RNITVIQEPG MVILEWLANP
     SNDMYADTVT TVILEVQSNP KIRKSAAQKV SKKLETHVYS KRLETMLQDI FGEDCVSVKD
     GSILSVTVDG KTANVNLDTR SVECEEGSED DESLREMVEL AAQRLHDALT PCACADRPAD
     HRLQLHTGVT WVLQTLQHLC KFSFQQGGWG AALAARLVRK CDVLNRGFSG YNTRWAKIIL
     PRLMGSGDSP AAVTVFFGAN DSSLREENPR QHVPLEEYAA NLSCMVRYLG SVGVAESRVI
     LVTPPPLCEA AWEEWCTAQG HRLNRRNSVA GEYARACVQV AHDYGTDVLD LWTLMQKDQD
     FSTYLSDGLH LSPKGNDFVF SHLWPLVEKK VSALPLLLPN WKDVAEANPE LSQLGEGGHS
     STS
//