ID A0A091DH48_FUKDA Unreviewed; 724 AA.
AC A0A091DH48;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 5 {ECO:0000313|EMBL:KFO22106.1};
GN ORFNames=H920_16486 {ECO:0000313|EMBL:KFO22106.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO22106.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO22106.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO22106.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN124131; KFO22106.1; -; Genomic_DNA.
DR RefSeq; XP_010605987.1; XM_010607685.2.
DR AlphaFoldDB; A0A091DH48; -.
DR STRING; 885580.ENSFDAP00000005347; -.
DR Ensembl; ENSFDAT00000018789; ENSFDAP00000005347; ENSFDAG00000014389.
DR GeneID; 104850635; -.
DR eggNOG; KOG3676; Eukaryota.
DR OMA; AYETHED; -.
DR OrthoDB; 1003028at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR CDD; cd22296; CBD_TRPV5_C; 1.
DR CDD; cd22192; TRPV5-6; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008346; TRPV5.
DR InterPro; IPR008344; TRPV5/TRPV6.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF11; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR01765; ECACCHANNEL.
DR PRINTS; PR01767; ECACCHANNEL2.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KFO22106.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 73..105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 157..189
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 322..582
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 650..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 82005 MW; E12721D4B282F297 CRC64;
MGAKGPWIQL QKLLSSWLVR EQDRDQQLDE ACMLQQKRIL ESPLLQGAKE NNLCTLKRLL
LGQSCDFRQR GALGETALHI AALYDNLEAA MLLMEAAPDL VMEPTLCEPY VGQTALHIAV
MNQNVNLVRA LLSHGASVSA RATGLAFEHS PHNLIYYGEH PLSFAACVGS EEIVRLLIEH
GADIRAQDSL GNTVLHILIL QPNKTFACQM YNLLLSYDRG DHLQCLEFVP NHQGLTPFKL
AGVEGNTVMF QHLMQKRKHI QWSCGPLTST LYDLTEIDSW GEELSFLELV VSSKKREARQ
ILEQTPVKEL VSLKWRKYGQ PYFCILGLLY ILYMICFTMC CVYRPLKLRN VNRTHSRDST
VLQQKLLQEA YVTYEDYIRL AGELVSVIGA VIILLIEIPD IFRVGASRYF GQTVLGGPFH
VIIISYASFV LVTMAMRLTN VNGEVVPLSL ALVLGWCSVM YFARGLQMLG PFTIMIQKMI
FGDLMRFCWL MGMVILGFSS AFFIIFQTED PSSLGEFSDY PTSLFSTFEL FLTIIDGPAN
YSVDLPFMYS ITYAAFAIIA TLLMLNLFIA MMGDTHWRVA QERDELWRAQ VVATTVLLER
KMPRFLWPRS GLRGCDYGLG DRWFLRVENH QDQNPLRVLR YVEAFKSSDK EDEQEQLSEK
QPSGNQSGTL ARASLTPQTP SLSRNTSQSS SSHRGWEILR RNTLGHLNLG LDIGEEDGEE
VYHF
//
