ID A0A091DHU7_FUKDA Unreviewed; 713 AA.
AC A0A091DHU7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|ARBA:ARBA00017391};
GN ORFNames=H920_06878 {ECO:0000313|EMBL:KFO31679.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31679.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31679.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31679.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004596}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004596}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KN122248; KFO31679.1; -; Genomic_DNA.
DR RefSeq; XP_010626305.1; XM_010628003.1.
DR AlphaFoldDB; A0A091DHU7; -.
DR STRING; 885580.ENSFDAP00000003540; -.
DR eggNOG; KOG4641; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFO31679.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..713
FT /note="Toll-like receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001873154"
FT DOMAIN 568..711
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 713 AA; 81160 MW; 4249FD127E14E24E CRC64;
MSRALWTVWL LGLVIRPSKE GSLGRASLSC DPAGVCDGRS RSFTSVPSGL SASVKSLDLS
NNRITSVGRR DLHRCVNLKT LVLKSSGIHT IEGDAFLSLG RLEHLDLSKN HLSELSSLWF
RPLSSLKFLN LLENPYQTLG EMSLFSHLSN LRILRVGNGA FIGMQKIDFA GLTLLEELEI
EASNIQSYEP QSLKSIQSIG HLILHMREPL FLMEVFVDIL GSVEHMGLSG TNLNEFSFSD
LSVSVTNSSI KKLTFRNVKF ADGSFNDVLR LSGYVPELLE VEFEDCIYNG IGNFGVSGIE
EVYPGKADTI TIRRLYIPNF YLFYDLSDMY SLAERFKRIT LENSKVFLVP CSLSRHLKSL
EYLDLSENLM VEENLGNAAC EGGWPSLQTL VLRKNHFTSI EKTGEVLLTL HNLTSLDISK
NSFHSMPEIC QWPEKMSYLN LSSTQIHRLT SCIPQTLEIL DVSNNDLSSL SLFLPRLQEL
YISRNKLKTL PEGSRLPALR VLKIRRNMIN TFSKEELDSF HGLQALEAGG NSFICSCDFL
SLAWERRGLP EVLSDWPAGY RCDSPRDLCF DAFVSYSERD ARWVEELLVQ ELEHRHPPLR
LCLHKRDFVP GKWILDNIID SIEKSRKTVF VLSQNFVKSE WCKYELDFSH FRLFDENDDA
AILVLLEPIE KKAIPQRFCK LRKIMNTRTY LEWPAEEARR EGFWANLRSA IKA
//
