ID A0A091DID3_FUKDA Unreviewed; 111 AA.
AC A0A091DID3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=TYRO protein tyrosine kinase-binding protein {ECO:0000256|ARBA:ARBA00022356};
DE AltName: Full=DNAX-activation protein 12 {ECO:0000256|ARBA:ARBA00031252};
GN ORFNames=H920_08560 {ECO:0000313|EMBL:KFO30050.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30050.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO30050.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO30050.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TYROBP family.
CC {ECO:0000256|ARBA:ARBA00009791}.
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DR EMBL; KN122516; KFO30050.1; -; Genomic_DNA.
DR RefSeq; XP_010630173.1; XM_010631871.1.
DR AlphaFoldDB; A0A091DID3; -.
DR STRING; 885580.ENSFDAP00000003617; -.
DR Ensembl; ENSFDAT00000017256; ENSFDAP00000003617; ENSFDAG00000013023.
DR GeneID; 104867497; -.
DR CTD; 7305; -.
DR eggNOG; ENOG502SCVI; Eukaryota.
DR OMA; FPECNCS; -.
DR OrthoDB; 4557845at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR009861; HCST.
DR InterPro; IPR026200; Tyrobp.
DR PANTHER; PTHR17554; TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN; 1.
DR PANTHER; PTHR17554:SF2; TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN; 1.
DR Pfam; PF07213; DAP10; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:KFO30050.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:KFO30050.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..111
FT /note="TYRO protein tyrosine kinase-binding protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001871703"
FT TRANSMEM 37..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 70..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 111 AA; 12062 MW; F6253F593D819B73 CRC64;
MGGLEPFWQL LLLPLLLTVA GVSPVQAQSG CNCTPMSAGV LAGIVLGDLV LTLLIALAVY
SLGRLVPRGR KTAQMARKQP ITETESPYQE LQGTRSDIYS DLNTQRQPYY K
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