ID A0A091DK27_FUKDA Unreviewed; 842 AA.
AC A0A091DK27;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN ORFNames=H920_06045 {ECO:0000313|EMBL:KFO32484.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32484.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO32484.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO32484.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; KN122157; KFO32484.1; -; Genomic_DNA.
DR RefSeq; XP_010624118.1; XM_010625816.2.
DR AlphaFoldDB; A0A091DK27; -.
DR STRING; 885580.ENSFDAP00000013126; -.
DR Ensembl; ENSFDAT00000025904; ENSFDAP00000013126; ENSFDAG00000006912.
DR GeneID; 104863430; -.
DR CTD; 1441; -.
DR eggNOG; ENOG502QT3H; Eukaryota.
DR OMA; SYCSIPR; -.
DR OrthoDB; 5354422at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..842
FT /note="Fibronectin type-III domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001872040"
FT TRANSMEM 629..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..231
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 236..333
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 335..434
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 530..625
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 738..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 92904 MW; 9156B6D8623FD535 CRC64;
MAGLGAGGLT GAALIILFLP GSLENCSHIS ISAHIVRLGD PVTASCTVSQ SCSHLDPEPR
ILWRLGTELL QQQGRQQRQP DGSQKSTVTL PYLNSTHTFL LCYLNWSNSL QLLNQAELWA
GYPPATPSNL SCLMNLTSNS LICQWEPGPE SHLPTNFTLK SFKSRGDCQT QEDTIKDCVP
AAGQSYCSIP RKHLLLYQNM VIWVQAENAL GTSLSPQLCL DPMDVVKLEP PTLLALDPNP
EVALPQPDCL WLRWEPWKPS LYMNQKCELR YRPQLGEASW AQVGPLPSST VQYELCGLRP
ATAYVLQMRC IRWPLPGPWS SWSPSLELQT AQGAPIVRLD TWWRQRQLDP KTTGVQLFWK
PTPLEEASGQ IQGYLLSWSP AGHAGPVLPL CNTTELSCTF RLPLGPGEVS LVAYNRAGTS
HPSPVVFLES TGPAPARLRA MARNPQCLWV GWDPPSPVPQ GYVIEWDLSP PSPSSSNTTW
RLESNGSITE TLLQENIRPF QLYEITVTPL YQGTMGHPKN VYVYSQEMAP PRMPVLHLKH
IGKTWAQLEW VPEASELGKI PLTHYTVFCT NTQDQSFSTV LNASSHDFVL RDLKPSTLYH
VHLMATSQAG ATNSTILTLM TLAQGESELH IFLGAFGILL LLILLYGLAW LCCSPSRKNP
LWPNVPDPAH SSLGSWVSTT MAEETFQLPS LRDPSITSIT KITMLEEEKK QPGPWESSDS
SETCGLPTLV QAYVLQRDPR ASSTQSQPQP GTSDQVFYGQ VLGSSTTPGP GHYIRCDSTQ
PLLEGLTPSP KSYENLWFQT IPLRMPGSPS PNQEDDCVFG PLLDFPLLQG LRVHGVEGLG
GF
//