ID A0A091DL13_FUKDA Unreviewed; 734 AA.
AC A0A091DL13;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Segment polarity protein dishevelled like protein DVL-1 {ECO:0000313|EMBL:KFO31752.1};
GN ORFNames=H920_06793 {ECO:0000313|EMBL:KFO31752.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31752.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31752.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31752.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DSH family. {ECO:0000256|ARBA:ARBA00008735}.
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DR EMBL; KN122247; KFO31752.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DL13; -.
DR STRING; 885580.ENSFDAP00000014912; -.
DR eggNOG; KOG3571; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0022603; P:regulation of anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd04438; DEP_dishevelled; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.240.130; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR024580; Dishevelled_C-dom.
DR InterPro; IPR008339; Dishevelled_fam.
DR InterPro; IPR003351; Dishevelled_protein_dom.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR PANTHER; PTHR10878:SF5; SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF02377; Dishevelled; 1.
DR Pfam; PF00778; DIX; 2.
DR Pfam; PF12316; Dsh_C; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR01760; DISHEVELLED.
DR PRINTS; PR01761; DISHEVELLED1.
DR SMART; SM00021; DAX; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 39..123
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT DOMAIN 289..361
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 463..537
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 127..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..267
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 79876 MW; 2BA8AC65F2DAFA3B CRC64;
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PTKIIYHMDE EETPYLVKLP
VAPERVTLAD FKNVLSNRPV HAYKFFFKSM DQDFGVVKEE IFDDNAKLPC FNGRVVSWLV
LAEGAHSDAG SQGTDSHTDL PPALERTGGI GDSRPPSFHP NVASSRDGMD NETGTESMVS
HRRERVRRRN REEATRANGH PRGDRRRDLG LPPDSASTVL SSELESSSFI DSDEEDNTSR
LSSSTEQSTS SRLIRKHKRR RRKQRLRQTD RASSFSSITD STMSLNIITV TLNMERHHFL
GISIVGQSND RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL QVNDVNFENM SNDDAVRVLR
EIVSQTGPIS LTVAKCWDPT PRSYFTVPRA DPVRPIDPAA WLSHTAALTG ALPRYGTSPC
SSAITRSSSS SLTSSVPGAP QLEEAPLTVK SDMSAIARVM QLPDSGLEIR DRMWLKITIA
NAVIGADVVD WLYTHIEGFR ERREARKYAG SMLRRGFLRH TVNKITFSEQ CYYVFGDLCS
DLAALNLHSG SSGASDQDTL APLPHPATAW PLGQGYPYQY PGPPPCFPPA YQDPGFSYGS
GSAGSQQSEG SKSSGSTRSS RRAPGREKER RAAGAGGSGS ESDPAALSGL GSAGWWERPV
SQLSQGSSPR SQASAVAPGL PPLHSLTKAY TVVGGPPGGP PVRELAAVPP ELTGSRQSFQ
KAMGNPCEFF VDIM
//
