ID A0A091DLP6_FUKDA Unreviewed; 1276 AA.
AC A0A091DLP6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Niemann-Pick C1-like protein 1 {ECO:0000313|EMBL:KFO33059.1};
GN ORFNames=H920_05675 {ECO:0000313|EMBL:KFO33059.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO33059.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO33059.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO33059.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN122106; KFO33059.1; -; Genomic_DNA.
DR RefSeq; XP_010623237.1; XM_010624935.1.
DR AlphaFoldDB; A0A091DLP6; -.
DR STRING; 885580.ENSFDAP00000021177; -.
DR GeneID; 104862741; -.
DR CTD; 29881; -.
DR eggNOG; KOG1933; Eukaryota.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1276
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001873520"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1138..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1165..1185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1242..1265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 632..797
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1276 AA; 140898 MW; 5B3DDC8A10883FC4 CRC64;
MAASLWGWLL WALLLCSVRG ELYTPIHQAS YCTFYEECGR NPELSGSLTA LSNVSCLSNT
QARLITGDHL ALLRRICPRL YAGPNTTYAC CSASQLVSLE MSMAITKALL TRCPACSDNF
VSLHCQNTCS PDQSLFINVT RVVPRGASEP PAVVAYEAFY QRSFAEEAYE SCSQVRIPAA
ASLAVGTMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLWEPSQALP AGIQPLDAMI
MRCNETQDNG TAACSCQDCA ASCPAILPPS NLRPFFYMGR LPGWEVLIII FCSVFVLLIA
VLAYFRVISK RREGGTQGLP RTPSPPKKHR CSPHTALGRF FESWGRRVAS WPLTFLAVSL
AVALGLASGL TFVRLTTDPV DLWSAPKSQA RREKEFHDQH FGPFFRTNQA FLTATNRSSY
MYNSLLLGPK NFSGVLSLDL LLEVLELQER VRHLQVWSAE AQRNISLQDV CYSPLKPHNA
SLSDCCVNSL LQYFQNNRSL LLLTANQTLM GQTAQVDWRD HFLYCANAPL TFKDGTALGL
SCMADYGAPV FPFLAVGGYK GKDYSEAEAL IMTFSLNNYP AGDPRMAQAR LWEEAFVQEL
AAFQKRMNGM FQVAFMAERS LEDEINRTTL KDLPVFAVSY IVIFLYISLA LGSYSRCDLV
PVESKATLGL GGVAVVMGSV VAAMGFYSYL DIPSSLIILQ VVPFLVLAVG ADNIFIFVLE
YQRMPRRPGE GREAHIGRAL GSVGPSMLLC SLSETICFFL GALTPMPAVR TFAMTSGLAV
FLNFLLQITA FVALLSLDSK RQEALRPDIF CCLAPRKLPP PDPKEGLLLS FFRKKYTPFL
LHGFTRPVVL LLFLALFGFS LYCMSHLVVG LDQQLALPKD SYLLDYFLFV NRYFEVGPPV
YFVTTSGYNF SSEAGMNAIC SSAGCDPFSL TQKIQYATEF PDQSYLAIPA SSWVDDFIDW
LTPSTCCRIY TLGPHKDEFC PSTENAFLCL KNCMSFTTGP LRPTVEEFHK YLPWFLTDLP
NINCPKGGMA AYSTSVNLSA DGQVIASQFM AYHKPLKNSQ DFTEALQATR LLANNITAEL
RKVPGTDPSF EVFPYTITNV FYQQYLTVLP EGVFTLALCF LPTFLVCYFL LGMDIRSGLL
NLLVIIMILV DTTGLMAMWD ISYNAVSLIN LVAAVGMSVE FVSHITRSFA ISTKPSRLER
AREATISMGS AVFAGVAMTN LPGILILSLA QAQLIQIFFF RLNFLITVVG LVHSLVFLPV
ILSYLGPDVN PALVLE
//
