ID A0A091DLT3_FUKDA Unreviewed; 600 AA.
AC A0A091DLT3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Keratin, type II cytoskeletal 75 {ECO:0000313|EMBL:KFO31448.1};
GN ORFNames=H920_07189 {ECO:0000313|EMBL:KFO31448.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31448.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31448.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31448.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KN122282; KFO31448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DLT3; -.
DR STRING; 885580.ENSFDAP00000017165; -.
DR eggNOG; ENOG502RTYA; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF13; KERATIN, TYPE II CYTOSKELETAL 75; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 149..511
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 146..252
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 309..336
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 409..489
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 65003 MW; 0750EBE7BBC15B89 CRC64;
MSRQSTITFH SGSHRGFSTA SATTPAAGRS RFSSVSVARS TGGSGGLGRI SGAGAGFGSR
SLYNLGGSKR VSIGGGSRGF RNGFGGRAGT GFGISNGFGY GSGVGGSFGG PGFPVCPSGG
IQEVTINQSL LTPLNLQIDP SIQRVRKEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK
WNLLQEQGSR TVKQNLEPLF DTYINDLRRQ LDGITTERGR QEAELRNMQE VVEDFKVRYE
DEINKRTAAE NEFVTLKKVT QVSSLSPPPP RPPGLNFLNP RLEGILPSFY WDDCLGLGSQ
RKLVLFQDVD AAYMNKAELE AKVDALTDQI NFHRVVFEAE LSQMQTQVSD TSVVLSMDNN
RNLDLDSIIA EVKAQYEDIA NRSRAEAESW YQTKYEELQV TAGRHGDDLR NTKQEISEVN
RMIQRLRAEI DSVKKQCSSL QTAIADAEQR GELALKDARA KLVDLEEALQ KAKQDMARLL
REYQELMNVK LALDVEIATY RKLLEGEECR LSGEGVSPVN ISVVTSTISS GYGSGSGIAS
GSLGLGGGSG YSFTTSGGHS LGTGLGGSGF TASSSRGPGG SGSSVKFIST TSSSRKNYKH
//
