ID A0A091DM38_FUKDA Unreviewed; 404 AA.
AC A0A091DM38;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Kringle-containing protein marking the eye and the nose {ECO:0000256|ARBA:ARBA00032328};
GN ORFNames=H920_14747 {ECO:0000313|EMBL:KFO23871.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO23871.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO23871.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO23871.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; KN123713; KFO23871.1; -; Genomic_DNA.
DR RefSeq; XP_010601920.1; XM_010603618.2.
DR AlphaFoldDB; A0A091DM38; -.
DR STRING; 885580.ENSFDAP00000002138; -.
DR eggNOG; KOG4157; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR24269; KREMEN PROTEIN; 1.
DR PANTHER; PTHR24269:SF15; KREMEN PROTEIN 2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF01822; WSC; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS51212; WSC; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..404
FT /note="Kringle-containing protein marking the eye and the
FT nose"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001872088"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..117
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 119..213
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 217..247
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
SQ SEQUENCE 404 AA; 43296 MW; 369455F044DA1B88 CRC64;
MGTRALLGLL LFLLLLQPHR AWAGSLNSPG LSECFQVNGA DYRGHQNHTG PRGTGRPCLF
WDQTQQHSYS SASDPQGRWG LGAHNFCRNP DGDVQPWCYV AETEEGIYWR YCDIPTCHMP
GYLGCFVDSG TPPALSGPSG TSTKLTVQVC LRFCRMKGYQ LAGVEAGYAC FCGSESDLAR
GLGAPATDCD QICFGHPGQL CGGDGRLGIY EVSVGSCQGN WTAPQGVIYS PDFPDEYGPD
RNCSWVVGPT GAALELTFRL FELADPRLQN VLEDRAQTKG LTQTPAETPG GANASCSPRP
VTLQAAIRAP VFSSVTVVSV LLLLLLLLLR LLRRRNCLLA PGKGPPALGP SRGPGRSWAV
WYRRPRGMAL PRPTGDPPAE GPAMGYLPLS ASSQSSLRSL ISAL
//
