ID A0A091DMI4_FUKDA Unreviewed; 512 AA.
AC A0A091DMI4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Pantetheinase {ECO:0000256|ARBA:ARBA00039352};
DE EC=3.5.1.92 {ECO:0000256|ARBA:ARBA00039042};
DE AltName: Full=Pantetheine hydrolase {ECO:0000256|ARBA:ARBA00043080};
DE AltName: Full=Vascular non-inflammatory molecule 1 {ECO:0000256|ARBA:ARBA00041612};
GN ORFNames=H920_06385 {ECO:0000313|EMBL:KFO32282.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32282.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO32282.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO32282.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Amidohydrolase that hydrolyzes specifically one of the
CC carboamide linkages in D-pantetheine thus recycling pantothenic acid
CC (vitamin B5) and releasing cysteamine. {ECO:0000256|ARBA:ARBA00037598}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantetheine + H2O = (R)-pantothenate + cysteamine;
CC Xref=Rhea:RHEA:13445, ChEBI:CHEBI:15377, ChEBI:CHEBI:16753,
CC ChEBI:CHEBI:29032, ChEBI:CHEBI:58029; EC=3.5.1.92;
CC Evidence={ECO:0000256|ARBA:ARBA00036605};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily.
CC BTD/VNN family. {ECO:0000256|ARBA:ARBA00008225}.
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DR EMBL; KN122191; KFO32282.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DMI4; -.
DR STRING; 885580.ENSFDAP00000013757; -.
DR eggNOG; KOG0806; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd07567; biotinidase_like; 1.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR InterPro; IPR012101; Biotinidase-like_euk.
DR InterPro; IPR040154; Biotinidase/VNN.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR043957; Vanin_C.
DR PANTHER; PTHR10609; BIOTINIDASE-RELATED; 1.
DR PANTHER; PTHR10609:SF16; PANTETHEINASE; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR Pfam; PF19018; Vanin_C; 1.
DR PIRSF; PIRSF011861; Biotinidase; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..512
FT /note="Pantetheinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001872101"
FT DOMAIN 31..307
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
FT ACT_SITE 80
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR011861-1"
FT ACT_SITE 179
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR011861-1"
FT ACT_SITE 212
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR011861-1"
SQ SEQUENCE 512 AA; 56825 MW; 9F5F2C7EBAD39056 CRC64;
MIPSQLFVSA AFSVFCVAKV ISLDTFIAAV YEHAVILPNA IPTPVSPEEA LALMNRNLDL
LEGAITAAAK QGAHIIVTPE DGIYGVNFTR DSIYPYLEDI PGPQVNWIPC DNPNRFGHTP
VQERLSCLAK DNAIYVVANI GDKKPCNSSD PQCPPHGRYQ YNTNVVFDSQ GKLVARYHKQ
NLFMGEEQFD TPKEVEIVTF DTAFGKFGIF TCFDILFHDP AVTLVKDFHV NTILFPAAWM
NVLPHLSAIE FHSAWAMGMG VNFLASNLHN PLKRMTGSGI YAPDFPRRFH YDMKTKEGKL
LLSQLDSRPY RPTVNWTSYA SGIEALPTGS QGFKGTVFFD EYIFVELKGI TGNYTVCQKD
LCCHLSYQMS EKRSDEVYAL GAFDGLHTAE GCYYLQICTL LKCKTTDLKS CGGSVDTAAT
RFEAFSLSGT FGTQYVFPEV LLSEVQLAPG EFQVTSDGRL LSLRPTSRPV LTVTLFGRLY
DKDETNGSPR LTAAMPRVLL MVITSVVYSL CW
//
