ID A0A091DML9_FUKDA Unreviewed; 722 AA.
AC A0A091DML9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Rho guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KFO24051.1};
GN ORFNames=H920_14560 {ECO:0000313|EMBL:KFO24051.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO24051.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO24051.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO24051.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN123665; KFO24051.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DML9; -.
DR STRING; 885580.ENSFDAP00000003412; -.
DR eggNOG; KOG3519; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 205..264
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 296..480
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 511..638
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 50..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 82852 MW; 4E72E7E4D71D67CF CRC64;
MPLLCPHAFS SALQNHVPWE GPPGEKPSCS HFHTEPAQKP LCTPRVVPWT LPSTAAEDTP
REAPPQPRRP FEHSRVSWDD LWLEKMQGKK PEKQVQIQKM CVERAHRAGV QCWRKMTAAS
PESLHLPRRS QTLSQSAPSG LNLTGWPEHT PDTAMPDGTL DTAIRAEEAG SEEDLYEDLH
SSSHHYSHPA GGGEQLAINE LISDGSVVCA EALWDHVTMD DQELGFKAGD VIEVMDATNR
EWWWGRVTDG EGWFPASFVR LRVNQDEPVE DDEAPQAQNG EAEDGGAEVQ SSKDQMRTNV
INEILSTERD YIKHLRDICE GYIRQCRKRA DMFSEEQLHT IFGNIEDIYR CQKAFVKALE
QKFNSKSPHL SELGACFLEH QADFQIYSEY CNNHPNACVE LSRLTKLSKY VYFFEACRLL
QKMIDISLDG FLLTPVQKIC KYPLQLAELL KYTHPQHRDF KDVEAALHAM KNVAQLINER
KRRLENIDKI AHWQSSIEDW EGEDLLVRSS ELIYSGELTR VTQPQAKSQQ RMFFLFDHQL
IYCKKFHGCH PTRPHTTQRQ GGSQPDLLRR DVLYYKGRLD MDGLEVVDLE DGKDRDLHVN
IKNAFRLHCG ISGDSHLLCA RKPEQKQRWL KAFAREREQV QLDQETGFSI TEPQRKQAML
NASRQQATGK PKAVSRPCYL TRQKHPTVPV SRPQQQVLVL AEPRRKPSTF WHSISRLAPF
RK
//