ID A0A091DNG0_FUKDA Unreviewed; 589 AA.
AC A0A091DNG0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Cytochrome P450 2S1 {ECO:0000313|EMBL:KFO33659.1};
GN ORFNames=H920_05005 {ECO:0000313|EMBL:KFO33659.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO33659.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO33659.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO33659.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR EMBL; KN122065; KFO33659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DNG0; -.
DR STRING; 885580.ENSFDAP00000018273; -.
DR eggNOG; KOG0156; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11026; CYP2; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR24300:SF23; CYTOCHROME P450 2S1; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00022617};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022617};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 589 AA; 65097 MW; 40CC612F4B98F9BF CRC64;
MNVAKLSITG LTESAPNLGD TLDSDYTTFQ QYLLLMGHCL KHGLRAKKTF LVIADDPIKT
LQMEPHRPGI PCDMAVRGQD SSIKESKTHV SQKLQPETVE DPSILEAVDG LRYLKGIACG
HLSDVNLAAT PSPSSKEWYL KVSGLSKKHG PVFTVHLGPW RHVVVLVGHK AVQEALGEQA
EGFSGRGILA TLDQTFDGHG VFFANGERWK QLRKFTMLAL RDLGMGRREG EELMQAEVQR
LVEAFQGTEG RPFDPSLLLA QATSNIVCLL LFGLRFSYED EEFQAVVRAA GGTLLGISSP
WGQTYEMFSW FLQPLPGPHT QLLRHLGTLA AFTAQQVQQH RGNLDTSGPA RDLVDAFLLK
MAQEEQNPST EFTEKNLLMT VTYLLFAGTM TVGATVRYAL LLLLKYPEVQ KKVREELTRE
LQAGQAPSLG DRARLPYTDA VLHEAQRLLA LVPMGIPHVV TRTTQFRGYT LPQGTEIFPL
LGSVLHDPEV FEQPGEFNPG RFLDAEGRFK KPEAFLPYSL GKRICLGEGL ARAELFLFFT
AILQAFSLDS PCPPDALSLQ PAVSGLFNIP PAFQLQVRPA DHHPAVQTR
//
