ID A0A091DPI3_FUKDA Unreviewed; 2056 AA.
AC A0A091DPI3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Tumor suppressor p53-binding protein 1 {ECO:0000313|EMBL:KFO32992.1};
GN ORFNames=H920_05608 {ECO:0000313|EMBL:KFO32992.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32992.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO32992.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO32992.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KN122106; KFO32992.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000014604; -.
DR eggNOG; KOG3548; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd17745; BRCT_p53bp1_rpt1; 1.
DR CDD; cd17724; BRCT_p53bp1_rpt2; 1.
DR CDD; cd20383; Tudor_53BP1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR015125; 53-BP1_Tudor.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR047249; BRCT_p53bp1-like_rpt1.
DR InterPro; IPR047250; BRCT_p53bp1-like_rpt2.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR047252; TP53BP1-like.
DR PANTHER; PTHR15321:SF3; TP53-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR15321; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; 1.
DR Pfam; PF09038; 53-BP1_Tudor; 1.
DR Pfam; PF18428; BRCT_3; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 1856..1932
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1948..2048
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 22..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1663..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1781..1804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1668..1691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2056 AA; 221491 MW; 6B30B8E7A82F53DB CRC64;
MAAVPGKGLQ AWSGWGGPAA CRRAGGTLRG PEASSGELKQ PFGGRWRREQ MDPTGSQLDS
DFSQQDTPCL IIEDSQPESQ VLEDDSGSHF SVISRHLPNL QTHKEDPVLD VVSNPEQTAE
QGDQNSGLSE HLKENKATDP VDSSHLDTCS SISQVIERLP QPNRTSSVVG MSLEPIPAVG
EEKEEESAEQ GTEGVEEDTS ADPTHSLSAE DPASSQLGFG VLELSQSQDV EGRTVPYEVD
REQPQLITTA SAYTRLSNVD ADAAVKHEER CGGDAPVTLQ PSQVGHVVEE PSPAVGRSED
LPSSPKVSHA AMETKEQTSV QELLEGELQI EKSPEPEVFS TQEDLFDQSN KTASDGCCTP
SKEEGGCSLA STPATTLQVL QLSGQRSLVQ ESLSMNSSDL VAPSPDAFRS TPFIVPSSPT
EQEGRKDEPV DMSLVSEGVG GPFQKRLQAS DPMQIENTPL PPAGAGSPQA STPVSQSTPV
FTPGSLPVPS QPEFSHDIFI PSPSLEEQSN DGKKGGDLHN SSLTIECSKT LEIEPKNSTE
DLGLSLTGDS CKLILSTSEY SQSSKMESLS SHRIDEDGEN SQVEDTEPLS PVLSSELVPV
ESDMNPASDG QVELSQNDDK TKGDDAENRD DISILATGFK GTEETVAEDI CIDLTCDSGS
QAVPSPATRT ETLSSVLDQE EAMEVTEHHP EEGSSGSEVE EIPETPCESH GEEPKEENPE
GVPFHLSLAE TQSQGLCLQK EIPKQECPEA MDVETSVISI DSPQKLPVLD QELEQKDQEA
WEEATSEGSS VVIVDVKGPL SPSVDVSGEP SEGMEKCSDS QSWDDVAPEI EPCAETRLEP
QEDKNIEYDG DQKSVTTEKE PVGEDPAQPP LPLVRAEEPP RPDQEMQQPQ LQEKTNKSLT
EDSKMANAKP LGSGREPGQL EKASAHASQS FCESSSETPF HFTLPKEGDT IPPLTGATPP
LIGHLKLEPK RHSTPIGISN YPESTIATSV VMSESMVETN EAILGSVKGD SGTAPEVDEK
LCLRMKLVSP ETEASEESLQ FSLEKPATGE RRNGSTAVAE AVASPQKTVS VFGCICEARQ
GDKAQGEDLP SASIRGSLLH FPSTQEEEKK AKLEGDHRIR QSEQPVKTVS LLEDPESPAS
QQTVSQGLSS PQGEAMEIDT QEGQHEERDA HQEKPSKALI ERPTQNNIGI QTLEQSLWVP
ETVSAATQTV KNVCEQGTST VDQSSGKQDA TVQTERGSDE KPIGTPGEDT ESLQSQGEEE
FDMPQPPQGH VLHRHMRTIR EVRTLVTRVI TDVYYVDGTE VERKVTEETE EPIVECQECE
TEVSPSQMGG SSGDLGDISS FSSKASSLHR TSSGTSLSAL HSSGSSGRGA GPLKGKTSGT
EPTDFALPSS RGGPGKLSPR KGINQTGAPV CEEDGDAGLG VRQGGKAPGT PRGRGRRGRP
PSRTTGTREA VLPGPLGIED ISPSMSPDDK SFTRILPRVP DTTRRADVGA GALRRSDSPE
IPFQAAAGSS DGLDTSSPGN SFVGLRVVAK WSSNGYFYSG KITRDVGAGK YKLLFDDGYE
CDVLGKDILL CDPIPLDTEV TALSEDEYFS AGVVKGHRKE SGELYYSIEK EGQRKWYKRM
AVILSLEQGN RLREQYGLGP YEAVTPLTKA ADISLDNLVE GKRKRRSNIS SPATPAASSS
SSTTPTRKVT ESPRASVGVP SGKRKLVTSE EDRSPAKRGR KSATVKPGAV GAGEFMSPCE
SGDYTVDPSV LEEQRGPLPL NKTLFLGYAF LLTMATTSDK LASRSKLPDL PTGSSEEEEG
SDGGMLTDVI LQEGIEIGEG GCHKLAPVMI RPEVTVLCVL SPFRNSKEFL EIPPFNKQYT
ESQLRAGAGY ILEDFNEAQC NTAYQCLLIA DQHCRTRKYF LCLASGIPCV SHVWVHDSCH
ANQLQNYRNY LLPAGYSLEE QRILDWQPRE NPFQNLKVLL VSDQQQNFLE LWSEILMTGG
AASVKQHHSS AHNKDIALGV FDVVVTDPSC PASVLKCAEA LQLPVVSQEW VIQCLIVGER
IGFKQHPKYK HNYVSH
//
