ID A0A091DPR0_FUKDA Unreviewed; 921 AA.
AC A0A091DPR0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 5 {ECO:0000313|EMBL:KFO32225.1};
GN ORFNames=H920_06328 {ECO:0000313|EMBL:KFO32225.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32225.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO32225.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO32225.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL11 family.
CC {ECO:0000256|ARBA:ARBA00010537}.
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DR EMBL; KN122191; KFO32225.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DPR0; -.
DR STRING; 885580.ENSFDAP00000015802; -.
DR eggNOG; KOG4279; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000165; P:MAPK cascade; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 3.30.1550.10; Ribosomal protein L11/L12, N-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR036796; Ribosomal_uL11_N_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF332; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54747; Ribosomal L11/L12e N-terminal domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:KFO32225.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW Transferase {ECO:0000313|EMBL:KFO32225.1}.
FT DOMAIN 597..855
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 626
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 921 AA; 104310 MW; D134122A58656223 CRC64;
MTTFVGAVLT ANNNPPIFRP SPDIGFAELY KTTSDIAVVE MSDAFRQPSL FYHLGVRESF
SMANNIILYC DTNSDSLQSL KVGDDIAKAT GDWKGLRITV KLTIQNRQVQ TEEEIICQKN
TMCTGNYSFI PYMVTPHNKV YCCDSSFMKG LTELMQPNFE LLLGPICLPL VDRFIQLLKV
AQVSSSQYFR ESILNDIRKA RNLYTGKELA AELTRIRQRV DNIEVLTADI VINLLLSYRD
IQDYDSIVKL VETLEKLPTF DLASHLHVKF HYAFALNRRN LPGDRAKALD IMIPMVQSEG
QVASDMYCLV GRIYKDMFLD SNFTDTESRD HGASWYKKAF ESEPTLQSGI NYAILLLAAG
HQFESSFELR KVGVKLSSLL GKKGNLEKLQ SYWEVGFFLG ASVLANDHLR VIQASEKLFK
LKTPAWYLKS IVETILIYKH FVKLTTEQPV AKQELVDFWM DFLVEATKTD VTVVRFPVLI
LEPTKIYQPS YLSINNEVEE KTISIWHVLP DDKKGIHEWN FSASSIRGVS ISKFEERCCF
LYVLHNSDDF QIYFCTELHC KRFFEMVNTI TEEKGRSVEE GDCEGDSLEY DYEYDENGDR
VVLGKGTYGI VYAGRDLSNQ VRIAIKEIPE RDSRYSQPLH EEIALHKHLK HKNIVQYLGS
FSENGFIKIF MEQVPGGSLS ALLRSKWGPL KDNEQTIGFY TKQILEGLKY LHDNQIVHRD
IKGDNVLINT YSGVLKISDF GTSKRLAGIN PCTETFTGTL QYMAPEIIDK GPRGYGKAAD
IWSLGCTIIE MATGKPPFYE LGEPQAAMFK VGMFKVHPEI PESMSAEAKA FILKCFEPDP
DKRACANDLL EDEFLKVSSK KKKTQPKLSA LSAGSNGVPE QPTFGSAQEV VFDPPKPFSR
RVTCSSFICF SYHSALVTMP T
//