ID A0A091DSY5_FUKDA Unreviewed; 385 AA.
AC A0A091DSY5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Homeobox protein OTX2 {ECO:0000313|EMBL:KFO25916.1};
GN ORFNames=H920_12682 {ECO:0000313|EMBL:KFO25916.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO25916.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO25916.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO25916.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000256|ARBA:ARBA00006503}.
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DR EMBL; KN123304; KFO25916.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DSY5; -.
DR STRING; 885580.ENSFDAP00000021490; -.
DR eggNOG; KOG2251; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003022; Otx2_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR PANTHER; PTHR45793; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45793:SF2; HOMEOBOX PROTEIN OTX2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01257; OTX2HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 133..193
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 135..194
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 190..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 42487 MW; F32E2F2A4866C9FF CRC64;
MPPSTNRLNA KKQIHKYNRV CCCSYVTGGL RKQCLSRAVC NFQIDKKRLE DKEHVLTVPP
VQNYPPRTLN LSTPGESRPS GWVPSIWADF APPNNLSMMS YLKQPPYAVN GLSLTTSGMD
LLHPSVGYPA TPRKQRRERT TFTRAQLDVL EALFAKTRYP DIFMREEVAL KINLPESRVQ
VWFKNRRAKC RQQQQQQQNG GQNKVRPAKK KTSPAREVSS ESGTSGQFTP SSTSVPTIAS
SSAPVSIWSP ASISPLSDPL STSSSCMQRS YPMTYTQASG YSQGYAGSTS YFGGMDCGSY
LTPMHHQLPG PGATLSPMGT NAVTSHLNQS PASLSTQGYG ASSLGFNSTT DCLDYKDQTA
SWKLNFNADC LDYKDQTSSW KFQVL
//
