ID A0A091DUL1_FUKDA Unreviewed; 447 AA.
AC A0A091DUL1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Tektin {ECO:0000256|RuleBase:RU367040};
GN ORFNames=H920_03780 {ECO:0000313|EMBL:KFO34752.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34752.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34752.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34752.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. Required for normal sperm mobility.
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SIMILARITY: Belongs to the tektin family.
CC {ECO:0000256|ARBA:ARBA00007209, ECO:0000256|RuleBase:RU367040}.
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DR EMBL; KN121905; KFO34752.1; -; Genomic_DNA.
DR RefSeq; XP_010618843.1; XM_010620541.2.
DR RefSeq; XP_010618844.1; XM_010620542.2.
DR AlphaFoldDB; A0A091DUL1; -.
DR STRING; 885580.ENSFDAP00000016302; -.
DR Ensembl; ENSFDAT00000007304; ENSFDAP00000016302; ENSFDAG00000004715.
DR GeneID; 104859767; -.
DR CTD; 150483; -.
DR eggNOG; KOG2685; Eukaryota.
DR OMA; RNLEDTH; -.
DR OrthoDB; 2875854at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:UniProtKB-UniRule.
DR InterPro; IPR048256; Tektin-like.
DR InterPro; IPR000435; Tektins.
DR PANTHER; PTHR19960; TEKTIN; 1.
DR PANTHER; PTHR19960:SF12; TEKTIN-4; 1.
DR Pfam; PF03148; Tektin; 1.
DR PRINTS; PR00511; TEKTIN.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367040};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367040};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846, ECO:0000256|RuleBase:RU367040};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT REGION 71..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 308..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 381..415
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 71..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 51430 MW; B5C2D83B66F0438B CRC64;
MAQTDVLLTQ QPAPQTVPPC ALPPKEYEVA CNTGVHTSSG LATTGFRTAK YLADEWFQNC
YARYHQALAD RDTSERQRHE SRQLAAETEA LAERTQQDST RRLGERLQDA HCWKSELQQE
VDALAAETDL LQAQKQRLEC ALDATSLPFS MASDQLQCCE RRQHPDLVRD HVEMELLKEA
ELIRNIQQLL KRTILQAVDQ TRLNREHKET CERDWSDKVE AYNIDETCCG YHSQSTEVQL
HPHSAAFEES ASTPETWAHF TRDNLLRAER ERQASANLRT LIDAILRDTA EDLRLQCDAV
NLAFASRCEE LEDARQKLQY HLQKTLREIT DQEQQAAALK QAIKDKEAPL RVAQSRLYQR
SQRPNVELCR DAAQLRLLSE VEELNLSLSL LREKLQEAQQ ALHNLEDTRM CLEKDIAVKT
NSLFVDRRKC MAHRTRYPTV LQLAGFQ
//
