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Database: UniProt
Entry: A0A091DWC3_FUKDA
LinkDB: A0A091DWC3_FUKDA
Original site: A0A091DWC3_FUKDA 
ID   A0A091DWC3_FUKDA        Unreviewed;       727 AA.
AC   A0A091DWC3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 5 {ECO:0000313|EMBL:KFO36439.1};
GN   ORFNames=H920_02188 {ECO:0000313|EMBL:KFO36439.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36439.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO36439.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO36439.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR   EMBL; KN121427; KFO36439.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091DWC3; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR   PANTHER; PTHR11905:SF28; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 5; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00276}; Integrin {ECO:0000313|EMBL:KFO36439.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT   DOMAIN          191..388
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   DOMAIN          400..489
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50214"
FT   DISULFID        344..349
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ   SEQUENCE   727 AA;  81217 MW;  9C4F74A49BCC23A5 CRC64;
     MREKEQGSRV VNTLASLQLQ LPPILSLTAT FLYRFQRSPL LPDPWTPQDE VWKSDLLLTL
     GSYSLNAIVK SFLASASVVY SYDKNGAQHS QSLLPRMDCS YSGYVVGFPH SLVALTTCSG
     LRGVMQFKNI SYGIEPLEAM SGFMHMIYEE SNNDTHVPLF GENDTYAWLN TAKSKVRSGL
     HKTEFTKLFP RYIEMYIIVD KNLFVYMGSD VKTVTLKVIR LIGFVNTMLT QLKLTVVIST
     IELWSNTNKF ATTGHPDDVL FRFLQWKHQH ADPKPHYISY LLAFEKHPTR IGATFPGYMC
     GNKYDAGVAL YPVGLSLESY AVIIVQLLGL NVGLVYDNTD TCHCLGDICT MTPKAAYSGV
     LTHFSTCSLD SFKSLASRSG LDCLKNNPHD KPVYKQSSRK RICGNSVREE GEECDCGTKL
     NCTHTKCCDP TSCRKKGSVV CGSGECCTTD CQLKKANTLC RPSIDKECDF DEFCTGKQGD
     CVPDTYARDG SHCDAGGAFC FGGICRTFDR QCQSLIGGDS RGAPFACFEE VNSRGDSYGN
     CGHNFCQLQH VLCGKLVCTW PHKRLVSREN LSVVYTHVRN DICVAGEKTV RKTVRASLST
     YLEHTDRDET FVEDGSMCGP DMVTTYFKLL LKIEVIFTLI LYQPIYLSQH YYSGKMHVTK
     IPILTILKCV ISSIKDIHNV QLSPSCFLIT RLFCFVETGS HDVVETDLKL CSPGWSRTYR
     DPPASAF
//
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