ID A0A091DWG6_FUKDA Unreviewed; 1623 AA.
AC A0A091DWG6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Alpha-protein kinase 3 {ECO:0000313|EMBL:KFO34630.1};
GN ORFNames=H920_03998 {ECO:0000313|EMBL:KFO34630.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34630.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34630.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34630.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type
CC protein kinase family. ALPK subfamily. {ECO:0000256|ARBA:ARBA00008651}.
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DR EMBL; KN121930; KFO34630.1; -; Genomic_DNA.
DR RefSeq; XP_010619418.1; XM_010621116.2.
DR STRING; 885580.ENSFDAP00000009972; -.
DR GeneID; 104860096; -.
DR CTD; 57538; -.
DR eggNOG; ENOG502QPP5; Eukaryota.
DR OrthoDB; 5321836at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR47091; ALPHA-PROTEIN KINASE 2-RELATED; 1.
DR PANTHER; PTHR47091:SF1; ALPHA-PROTEIN KINASE 3; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFO34630.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 60..156
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1194..1282
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1310..1545
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1548..1623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..672
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1623 AA; 173388 MW; 0B8F15E5FEDB9C9B CRC64;
MGSRRVPGWG IGGRSGGDSE DDGPVWTPSP ASRSYLLSVR PETRSTFCSI IAQLTEETQP
LFETTLKSRA VSEDSDVRFT CIVTGYPEPE VTWYKDDTEL DRYCGLPKYK ITHQGNRHTL
QLYRCQEEDA AIYQASARNT KGIVSCSGVL EVGTMTEYKI HQRWFAKLKR KAAAKMRELE
QSWRQGKEFP GEAEVLRKLS PDRFQRKRRL SGPGVPIPSA PCPPREAKDE APEVWQEGKT
ESVRHPGLGL VNNFAAGGEA PTNGEPAPEN GEDREHGLLT YICEAMELEP SKAPQKESGA
KKKRKDRESK LGLRTLVSEK TARGHKSAEN CVSSSDKADS GGTQRPVGTE QVQAQCRSRA
AWGSGSSRTD TIRKPAPAVD TQDKAHDGPA QSPVEAPDTS PAPGPGQEGF FSLKDLYVES
TLEARPQGQG EPLPPSAEGP PGKVLIGSRG AEMSTDPGQH TPSVAPHSAR PFNRKRFAPP
KPKGEPHTDS QPASSLKGAP DCEVQNSRQA LPQASAQVPT PPARWKHSSR DSPVQGRAGH
RPSGEEPQAT TAQTMSASNS SSAAPTGHSS SGNQRVVEPM DIKAQEDRRT HTDDRRTRGR
KSPQVQVVGR TEGERAQAAQ RTQVDVVMQE SESPQSDRSS QKDVVMQRRV ETQVERILAD
ERTQENRRMQ EGEQTQPEGS VLPATESHPE QQSVTSLSPL PRAPESLPSE GPRSSELTEC
PTQTPEASSV PEEPGFVLTS EEPPVNTSGS HEDTVLGPLP ASFLCPAQLP CEGSSEHRGG
ERHLEPEESG PAKAEQEVQP GAVPFVALGG CPTGSSSLGV SIKPSLPGPG LTNNLQEELP
STPAPQPTDT AGHQAGLSSV PTMHQGPEPH TQSPLLETVA TSSKGACAKE PIIEDSLPAS
RSCDPGLIDS LKNYLLLLLK LSSTESGEAV TESPVGAATV GTALSPPLVP TVEVAGLSPR
TSRRILERVE NNHLVQSAET LLLSPCTSRR LTSLLDQEVQ AGRQALASAQ AARGPGPSPL
SVPAIVVGEE VPGVASEGSL EGPGLQSGQV AETKAHKPCQ EEREPGEALP GLPAATPEEL
ALGARRKRFV PKVRAAGDGE VAKSEERESP SVSPRGPRKN LAPGSPGTPG RERRSPTQGK
KAMLEVPRAE EEPVAGELGS SPKAGGPDAE PALDEDTQDP VAKTQKAKDL LKAPQVIRKI
RVEQFPDASG SLKLWCQFFN ILNDSVLTWA KDQHPVGEVN RSAGDEGPAA LAIVQASPVD
CGVYRCTIHN EHGSASTDFC LSPEVLSGFI SREEGEVGEE IEMTPMVFAK GLADSGCWGD
KLFGRLVSEE LRGGGHGGGL QKASRAKVIY GLEPIFESGR TCIIKVSSLL VFGPSSETSL
LGRNYDVTIQ GCKIQNMSRE YCKIFAAEAR AAPSFGEVPE IVPLYLIYRP ANTIPYATLE
EDLGKSLQSY CSREGGCTGA PAAPSSSEIV QKCQAFQHWL YQWTNGSFLV TDLAGVDWKM
TDVRIATKLR GYQGLKESCF PALLNHFASS HQCNAYCEML GLTALKGPEA SHPQAKPKVS
KSPSAGRKGT QLSPQPQKKG PPSPQGTRRS TPSPKATSQA SEAAAVPGLG QPPSQEGGSK
AHR
//
