ID A0A091DWU9_FUKDA Unreviewed; 1108 AA.
AC A0A091DWU9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=H920_03768 {ECO:0000313|EMBL:KFO34740.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34740.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34740.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34740.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; KN121905; KFO34740.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DWU9; -.
DR STRING; 885580.ENSFDAP00000020059; -.
DR eggNOG; KOG0474; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR029512; CCDC154.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002249; Cl_channel-7.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF15450; CCDC154; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01118; CLCHANNEL7.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 115..141
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 273..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 360..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 396..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 473..491
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 503..526
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 532..554
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 566..587
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 616..680
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 726..784
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 123828 MW; 789B32C16BD59BBC CRC64;
MANVSKKVSW SGRDLDDEEA TPLLQRTVRP GDGTPLLNGA GPAARQMSGM EVGEELRDLE
VNFPHPFPKE IPHNEKLLSL KYESLDYDNS ENQLFLEEER RINHTAFRTV EIKRWVICAL
IGILTGLVAC FIDIVVVALP LLDKPADIDK FTEKGGLSFS LLLWATLNSA FVLLGSVIVA
FIEPVAAGSG IPQIKCFLNG VKIPHVVRLK TLVIKVSGVI LSVVGGLAVG KEGPMIHSGS
VIAAGISQGR STSLKRDFKI FEYFRRDTEK RDFVSAGAAA GVSAAFGAPV GGVLFSLEEG
ASFWNQFLTW RIFFASMIST FTLNFVLSIY HGNMWDLSSP GLINFGRFDS EKMAYTIHEI
PVFIAMGVVG GILGAVFNAL NYWLTMFRIR YIHRPCLQVI EAMLVAAVTA TVAFVLIYSS
RDCQPLQGNS MSYPLQLFCA DGEYNSMAAA FFNTPEKSVV SLFHDPPGSY NPMTLGLFTL
VYFFLACWTY GLTVSAGVFI PSLLIGAAWG RLFGISLSYL TGAAIWADPG KYALMGAAAQ
LGGIVRMTLS LTVIMMEATS NVTYGFPIML VLMTAKIVGD VFIEGLYDMH IQLQSVPFLH
WEAPVTSHSL TAREVMSTPV TCLRRREKVG IIVDVLSNTA SNHNGFPVVE DSEDTQPARL
QGLILRSQLI VLLKHKVFVE RSNMGLVQRR LRLKDFRDAY PRFPPIQSIH VSQDERECTM
DLSEFMNPSP YTVPQEASLP RVFKLFRALG LRHLVVVDNR NQVVGLVTRK DLARYRLGKG
GLEELSLAQT AVNLEDLELL LVEDSAIPDP LSLEENSERN ESSPLVSSPP ALEQDNSKLL
EERLAKLQAE VLSLRGHKVH CEQASLSLLR ELLHVRGRMQ LHSSELWQLW QEMQRVAQVP
EREVQVLPGA QNQNLMQILD KRLAKLTGWL RQEEQARETA CSTLQKSQED TSQQVDHEMA
KMQAQLTKIG EEMSLRFLKR EAKLCSFLQK SFLTLEQRTK ALEGTQLEAE SHLREELEDH
WQRLQELTEE RVQALWAQRE QEEHGCLREQ CRGLDAAMIR LTKFVRQNQM SLSHILLMEQ
EAWVSKVGLE ESQAGELASY VQENLEAV
//
