ID A0A091DXZ7_FUKDA Unreviewed; 1125 AA.
AC A0A091DXZ7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Protein transport protein Sec24C {ECO:0000313|EMBL:KFO36999.1};
GN ORFNames=H920_01646 {ECO:0000313|EMBL:KFO36999.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36999.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO36999.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO36999.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; KN121161; KFO36999.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DXZ7; -.
DR STRING; 885580.ENSFDAP00000021092; -.
DR eggNOG; KOG1984; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF5; PROTEIN TRANSPORT PROTEIN SEC24C; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 448..486
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 525..774
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 779..862
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 875..974
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 993..1066
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 122188 MW; CC5C48A1E4A97BBE CRC64;
MNVNQSAPPV PPIGQPQPIY PGYHQSSYGG QPGSTAPPTP YGAYNGPVPG YQQTPPLGMS
RAPPSSGAPP TSTAQASCGQ AGYGQFGQGD IQNGPSSSTV PMQRLPGSQP FRSPLASAVS
QPAVLQSYGP PPPTSTQVTA QLAGMQISGA MAPAPPPSGL GYGPPTSLAS ASGSFPNSGP
YGSYPQGHAP PISQAQGHPG VQPPQQSAPL RASSFTPPAS GVPRMPSMTG PLPPGQGFGG
PPMSQPNHVS SAPPQVLPPG TQMTGPQGPP PPMHSPQQPG YQLQQNGSFG PGRGPQPNYG
SPYPGAPTFG SQPGPPQPLP PKRLDPDAIP SPQLNELPPQ QKTRHRIDPD AIPSPIQVIE
DDRNNRGSEP FVTGVRGQVP PLVTTNFLVK DQGNASPRYI RCTSYNIPCT SDMAKQAQVP
LAAVIKPLAK LPPEEASPYV VDHGESGPLR CNRCKAYMCP FMQFIEGGRR FQCCFCSCIN
DVPPQYFQHL DHTGRRVDAY DRPELSLGSY EFLATVDYCK NNKFPSPPAF IFMIDVSYNA
IRTGLVRLLC EELKSLLDYL PREGGAEESA IHVGFVTYNK VLHFYNVKSS LAQPQMMVVS
DVADMFVPLL DGFLVNVNES RAVITSLLDQ IPEIFADTRE TETVFAPVIQ AGMEALKAAE
CSGKLFLFHT SLPIAEAPGK LKNRDDRKLI NTDKEKVWDW KTLFQPQTGV YQTLAKECVA
QGCCVDLFLF PNQYVDVATL SVVPQLTGGS VYKYACFQVE NDQERFLSDL RRDVQKVVGF
DAVMRVRTST GIRATDFFGC FYMSNTTDVE LAGLDGDKTV TVEFKHDDRL NEESGALLQC
ALLYTSCAGQ RRLRIHNLAL NCCTQLADLY RNCETDTLIN YMAKFAYRGV LNSPVKTVRD
TLITQCAQIL ACYRKNCASP SSAGQLILPE CMKLLPVYLN CVLKSDVLQP GAEITTDDRA
YIRQLVTSMD VAETNIFFYP RLLPLTKSPI ESTTEPPAVR ASEERLSSGD IYLLENGLNL
FLWVGASVQQ GVVQSLFNVA SFSQITSGLS VLPVLDNPLS KKVRGLIDSL RAQRSRYMKL
IVVKQEDKLE MLFKNFLVED KSLSGGESYV DFLCHMHKEI RQLLS
//
