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Database: UniProt
Entry: A0A091DZN5_FUKDA
LinkDB: A0A091DZN5_FUKDA
Original site: A0A091DZN5_FUKDA 
ID   A0A091DZN5_FUKDA        Unreviewed;      2780 AA.
AC   A0A091DZN5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   07-NOV-2018, entry version 18.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|EMBL:KFO36552.1};
GN   ORFNames=H920_02006 {ECO:0000313|EMBL:KFO36552.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36552.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO36552.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO36552.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN121399; KFO36552.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KFO36552.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2300   2322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2342   2360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2381   2405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2425   2453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2474   2496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2601   2624       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      186    240       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      247    297       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      305    361       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      368    431       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      452    508       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED      163    183       {ECO:0000256|SAM:Coils}.
FT   COILED     1670   1690       {ECO:0000256|SAM:Coils}.
FT   COILED     1996   2016       {ECO:0000256|SAM:Coils}.
FT   COILED     2711   2759       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2780 AA;  316853 MW;  3B8AFAF333D21DBE CRC64;
     MNSPLHPHSL VVLLDGRDRT VEMPILKDLA TVAFCDAQED LEKFKALRVI LWIDCGYDDV
     AIKAAGELGI AVCNIPSTAV EETADSTICH ILNLFWWNTW LYQALLVDDR CVVHPEAGDL
     ANPPKKFRDC LFKVCPMNRY SAQKQYWKAK QAKQGNHTEA ALLKKLQHAA ELEQKQNESE
     NKKLLGEIVK YSNVIQLLHI KSNKYLTVNK RLPALLEKNA MRVSLDAAGN EGSWFYIHPF
     WKLRSEGDNI VVGDKVVLMP VNAGQPLHAS NIELLDNPGC KEVNAVNCNT SWKITLFMKF
     SSYREDVLKG GDVVRLFHAE QEKFLTCDEY EKKQHIFLRT TLRQSATSAT SSKALWEIEV
     VHHDPCRGGA GQWNSLFRFK HLATGNYLAA ELNPDYRDAQ NEGKNQRDGD LPTSKKKRQA
     GEKIMYTLVS VPHGNDIASL FELDATTLQR ADCLVPRNSY VRLRHLCTNT WVTSTSIPID
     TDEERPVMLK IGTCQTKEDK EAFAIVSVPL SEVRDLDFAN DANKVLATTV KKLENGTITQ
     NERRFVTKLL EDLIFFVADV PNNGQEVLDV VITKPNRERQ KLMREQNILA QVFGILKAPF
     KEKGGEGPML RLEDLGDQRY APYKYALRLC YRVLRHSQQD YRKNQEYIAK NFCVMQSQIG
     YDILAEDTIT ALLHNNRKLL EKHITAKEIE TFVSLLRRNR EPRFLDYLSD LCVSNTTAIP
     VTQELICKFM LSPGNADILI QTKLVSLQVD NPMESSLLSD DIDDEEVWLY WIDSNKEPHG
     KAIRHLAQEA KEGTKVDLEV LTYYRYQLNL FARMCLDRQY LAINQISTQL SVDLILRCVS
     DESLPFDLRA SFCRLMLHMH VDRDPQESVV PVRYARLWTE IPTKITIHEY DSITDSSRND
     MKTKFALTME FVEEYLKEVV NQPFPFGDKE KNKLTFEVVH LARNLIYFGF YSFSELLRLT
     RTLLAILDIV QAPMSSYFER LSKFQDGGNN VMRTIHGVGE MMTQMVLSRG SLFPGSVPDV
     PPSAHPSKQA SPTEHEDITV MDTKLKIIEI LQFILSVRLD YRISYMLSIY KKEFGENNDP
     AETSVSGSPD TLVPSAIVPD IDEIAARAET MFAGRKEKNP VQLDDEGGRT FLRVLIHLIM
     HDYAPLLSGA LQLLFKHFSQ RAEVLQAFKQ VQLLVSNQDV DNYKQIKADL DQLRLTVEKS
     ELWVEKSSSY ENGEMGENQV KGSEEPNEES NILSPVQDGT KTPQIDSNKS NNYRIVKEIL
     VRLSKLCVQN KKCRNQHQRL LKNMGAHSVV LDLLQIPYEK NDEKMNEVMN LAHTFLQNFC
     RGNPQNQVLL HKHLNLFLNP GLLEAETMRY IFMNNYHLCN EISERVVQHF VHCIETHGRH
     VEYLRFLQTI VKADGKYVKK CQDMVMTELI NGGEDVLIFY NDRASFPILL HMMCSERDRG
     DDSGPLAYHI TLVELLAACT EGKNVYTEIK CNSLLPLDDI VRVVTHDDCI PEVKIAYVNF
     VNHCYVDTEV EMKEIYTSNH IWKLFENFLV DMARVCNTTT DRKHADIFLE KCVTESIMNI
     VSGFFNSPFS DNSTSLQTHQ PVFIQLLQSA FRIYNCTWPN PAQKASVESC IRTLAEVAKN
     RGIAIPVDLD GQVNTLFMKS HSNMVQRAAM GWRLSARSGP RFKEALGGPA WDYRNIIEKL
     QDVVASLEQQ FSPMVQAEFS VLVDVLYSPE LLFPEGSDAR IRCGAFMSKL INHTKKLMEK
     EEKLCIKILQ TLREMLEKKD SFVEEGSTLR KILLNRYFKG DYGVGMNGHL SGTYSKSAQG
     GGSFSVQDSD KMGISLSDIQ CLLDKEGASE LVIDVIVNTK NDRIFSEGIL LGIALLEGGN
     TQTQYSFYQQ LHEQKKSEKF FKVLYDRMKV AQKEIRSTVT VNTIDLGSKK RDDDNELMTS
     GPRMRVRDST LHLKEGMKGQ LTEASTATSK AYCVYRREMD PEIDIMCTGP EAGNADEKSA
     EEVTMSPAIA IMQPILRFLQ LLCENHNREL QNFLRNQNNK TNYNLVCETL QFLDCICGST
     TGGLGLLGLY INEKNVALVN QTLESLTEYC QGPCHENQTC IATHESNGID IIIALILNDI
     NPLGKYRMDL VLQLKNNASK LLLAIMESRH DSENAERILF NMRPRELVDV MKNAYNQGLE
     CDHGEEEGGD DGVSPKDVGH NIYILAHQLA RHNKLLQQML KPGADPDEGD EALKYYANHT
     AQIEIVRHDR TMEQIVFPVP NICEFLTRES KSRVFNTTER DEQGSKVNDF FQQTEDLYNE
     MKWQKKIRNN PALFWFSRHI SLWGSISFNL AVFINLAVAL FYPFGDDGDE GKIQSGTLSP
     LFSVLLWIAV AICTSTLFFF SKPVGIRPFL VSVMLRSIYT IGLGPTLILL GAANLCNKIV
     FLVSFVGNRG TFTRGYRAVI LDMAFLYHVA YVLVCMLGLF VHEFFYSFLL FDLVYREETL
     LNVIKSVTRN GRSIILTAVL ALILVYLFSI IGFLFLKDDF TMEVDRLKNR TPVTGNYEVR
     TVTLMSVVET CEKDNCSTTV PASNKADEEY EDGIERMCDT LLMCIVTVLN QGLRNGGGVG
     DVLRRPSKDE PLFAARVVYD LLFFFIVIII VLNLIFGVII DTFADLRSEK QKKEEILKTT
     CFICGLERDK FDNKTVSFEE HIKSEHNMWH YLYFIVLVKV KDPTEYTGPE SYVALMIVEK
     NLDWFPRMRA MSLVSNESDS EQNEIRNLQE KLESTMSLVK QLSGQLAELK EQMTEQRKNK
     QRLGFLGSNT PHVNHHMPPH
//
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