ID A0A091E0E0_FUKDA Unreviewed; 967 AA.
AC A0A091E0E0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=H920_10086 {ECO:0000313|EMBL:KFO28546.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO28546.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO28546.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO28546.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KN122754; KFO28546.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091E0E0; -.
DR STRING; 885580.ENSFDAP00000003012; -.
DR eggNOG; KOG0584; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14033; STKc_WNK4; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024678; Kinase_OSR1/WNK_CCT.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13902; SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED; 1.
DR PANTHER; PTHR13902:SF114; SERINE_THREONINE-PROTEIN KINASE WNK4; 1.
DR Pfam; PF12202; OSR1_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFO28546.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 50..308
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..689
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 104407 MW; 9A500A4E9FA78445 CRC64;
MQGEETCSLC PPSSPHGLGP RSANPCGPRC LRSLCLPPCL SQAGAGASEG QFDIEIGRGS
FKTVYRGLDT DTTVEVAWCE LQTRKLSRAE RQRFSEEVDM LKGLQHPNIV RFYDSWKSVL
RGQVCIVLVT ELMTSGTLKT YLRRFREMKP RVLQRWSRQI LRGLHFLHSR APPILHRDLK
CDNVFITGPT GSVKIGDLGL ATLKRASFAK SVIGTPEFMA PEMYEEKYDE AVDVYAFGMC
MLEMATSEYP YSECQNAAQI YRKVTSGTKP NSFYKVKMPE VKEIIEGCIR TDKNQRFTIQ
DLLAHAFFRE ERGVHVELAE EDDGQKPDLK LWLRMEDARR GGRPRGNQAI EFLFQLGRDV
AEEVAQEMVA LGLVCEADYQ PVARAVRERV AAIQRKREKL RTAREPEALP PKPGPVPVTI
PVAPGAPGAF PPEPEEPEAD QHQPFLFRHA SCSSTTSDCE TDGYLSSSGC LDASDPALAP
PGEVPPSPAK PWLHLPPAFA VSVPCSGPGS DFSPGDSYAS DAASGLSDMG EGMGQMRRPP
GKTPRRRPRS RLRVTSVSDQ NDRVVECQLQ THNSKTVTFR FDLDGDSPED IAAAMVYNEF
ILPAEREGFL RRIREVIQRV ETLLKRDPGP AEAAEDAPGP QEEPAPLPAH EDLPRELQSS
SGPGQRSWAA FCTSPTPPGT PPSPAAPVFP SPRLFSTSAQ PSSCPPQLPS CAFPFLTGAV
QAPSSLLPLG SLPCSPQSPL CPSPATPAAP LLSLASAFSL AVMTVAQSLL SPPPGTLAQC
PPAPPGPQPG LPPPPAPGGQ ENLLPYTAKA EAQSEATPNP TRPVLGEARL APISEEGKPQ
LVGRFQVTSS KEPVECPALQ PAASAALPGS PKPPTPPQSP ESSDTEDSAG GRPGTREALA
ESDRAAEGLG TVLDDGMDPR AGDSPLAPPS PVWTNYSYSS LCLSSEESES SGEDEEFWAE
LHSLRQK
//
