ID   A0A091E0T1_FUKDA        Unreviewed;       488 AA.
AC   A0A091E0T1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Fibroblast growth factor receptor substrate 3 {ECO:0000313|EMBL:KFO36150.1};
GN   ORFNames=H920_02362 {ECO:0000313|EMBL:KFO36150.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36150.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO36150.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO36150.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN121537; KFO36150.1; -; Genomic_DNA.
DR   RefSeq; XP_010615907.1; XM_010617605.1.
DR   AlphaFoldDB; A0A091E0T1; -.
DR   STRING; 885580.ENSFDAP00000005012; -.
DR   GeneID; 104857604; -.
DR   CTD; 10817; -.
DR   eggNOG; KOG4047; Eukaryota.
DR   OrthoDB; 2996885at2759; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01202; PTB_FRS2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR038742; FRS2_PTB.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR   PANTHER; PTHR21258:SF39; FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3; 1.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51064; IRS_PTB; 1.
PE   4: Predicted;
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Receptor {ECO:0000313|EMBL:KFO36150.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT   DOMAIN          13..115
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          155..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  53449 MW;  1A3020A9418B0736 CRC64;
     MGSCCGCLNR DSVPDNHPTK FKVTNVDDEG VELGMGVMEL TQSELVLHLQ RREAVRWPYL
     CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFSL LQDLMQCNSI NVTEEPVIVT
     RSSHPAEIDL PRTPQQPSAL GCAVSGFSNG CPGCPGEAPQ FSTPRQPSSS SLQQPSLGEE
     STHALIAPDE QSHTYVNTPA GEDDHRRSRH CLQPLPEGRV PFPTQAREAG TRDPQIFLQP
     GQVKFVLGPT PTRRHVLKCQ SLCPSLQDVP HHHNNNEGPS ECPSQPKCTY ENVGGGLRCG
     PGWRLSPEEP GWGGLAQRRA ALLHYENLPP LPPVWESHGQ PHSGEPGDDG DSRDGLTPSS
     NGFPEGDGEE DETPLQKPTS SRATARSHGG FPVPLTRRRG SPRVFSFDFR RPGPEPPRQL
     NYIQVELKGW GGERSKDPAA PRASAPSSDS YAVIDLKKTA AMSSLQRALP RDDGTARKTR
     HNSTDLPL
//