ID A0A091E148_FUKDA Unreviewed; 434 AA.
AC A0A091E148;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN ORFNames=H920_09723 {ECO:0000313|EMBL:KFO28781.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO28781.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO28781.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO28781.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of the MCIA complex, involved in the assembly of the
CC mitochondrial complex I. {ECO:0000256|ARBA:ARBA00029396}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; KN122676; KFO28781.1; -; Genomic_DNA.
DR RefSeq; XP_010633038.1; XM_010634736.2.
DR RefSeq; XP_010633039.1; XM_010634737.2.
DR RefSeq; XP_019064649.1; XM_019209104.1.
DR AlphaFoldDB; A0A091E148; -.
DR STRING; 885580.ENSFDAP00000022026; -.
DR Ensembl; ENSFDAT00000010487; ENSFDAP00000022026; ENSFDAG00000007279.
DR GeneID; 104869489; -.
DR CTD; 51295; -.
DR eggNOG; KOG3941; Eukaryota.
DR OMA; NMADFGV; -.
DR OrthoDB; 4098911at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
DR SMART; SM01284; ECSIT_Cterm; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 272..397
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01284"
FT REGION 44..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 49338 MW; EB305F68D7CE4534 CRC64;
MSCVRAVLLV QSLARGRAGI RRASHLGTPF PQVPPLALRS LHCSSAPHTS EKSEKSLVPR
PPESGKRLAK VPAPWEDLFH PAPGGTRDKA SFVRAVQSFE QHNVHKRGHV DFIYLALRKM
REYGVERDLA AYNLLLDIFP KEVFRPRNFI QQIFLHYPRQ QECGVAVLDQ MESNGVMPNK
ETKFLLLQIF GRGSHPMLKL ERMRLWFTRF QHINPFPVPR DLPHGAVELA TLGLQHMEPD
LSARVTVYQR PLPDDVTDPG DLIQPHIVGI QSPDQQDALA RHSPARPLFV EGPFSLWLRN
KCVYYHILRA DLLPPKEKDL EEIPEEWNLH YPMKLDLDYA RSGWDDYEFD IDEVEEGPVF
AMCVAGAHDQ ETLAKWIQGL QETNPALASI PVVFQLAGST GELLTASGPE DPRQSQREGR
EEDDHLQRQQ QGQS
//
