ID A0A091E2C6_FUKDA Unreviewed; 470 AA.
AC A0A091E2C6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Calcium/calmodulin-dependent protein kinase type II subunit delta {ECO:0000256|ARBA:ARBA00039734};
DE EC=2.7.11.17 {ECO:0000256|ARBA:ARBA00012434};
GN ORFNames=H920_09426 {ECO:0000313|EMBL:KFO29186.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO29186.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO29186.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO29186.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000902};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.17; Evidence={ECO:0000256|ARBA:ARBA00000517};
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}. Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00037846}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037846}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00037846}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. CaMK subfamily. {ECO:0000256|ARBA:ARBA00005354}.
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DR EMBL; KN122621; KFO29186.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091E2C6; -.
DR STRING; 885580.ENSFDAP00000006172; -.
DR eggNOG; KOG0033; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013543; Ca/CaM-dep_prot_kinase-assoc.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24347:SF365; CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA; 1.
DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF08332; CaMKII_AD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Kinase {ECO:0000313|EMBL:KFO29186.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transferase {ECO:0000313|EMBL:KFO29186.1}.
FT DOMAIN 1..231
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 308..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 52737 MW; DDBDC4C8507D10CD CRC64;
MKVSIGLTKS LQLTDNTADY LLSELIFLGQ GHFIASVGAP RRSGIMLAIS RVTGGELFED
IVAREYYSEA DASHCIQQIL ESVNHCHLNG IVHRDLKPEN LLLASKSKGA AVKLADFGLA
IEVQGDQQAW FGFAGTPGYL SPEVLRKDPY GKPVDMWACG VILYILLVGY PPFWDEDQHR
LYQQIKAGAY DFPSPEWDTV TPEAKDLINK MLTINPAKRI TASEALKHPW IFQRSTVASM
MHRQETVDCL KKFNARRKLK GAILTTMLAT RNFSGMCFFL FSAYPQINNK ANVITSPKEN
IPTPALEPQT TVIHNPDGNK ESTESSNTTI EDEDVKARKQ EIIKVTEQLI EAINNRDFEA
YTKICDPGLT AFEPEALGNL VEGMDFHRFY FENALSKSSK PIHTIILNPH VHLVGDDAAC
IAYIRLTQYM DGSGMPKTMQ SEETRVWHRR DGKWQNVHFH RSGSPTVPIK
//