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Database: UniProt
Entry: A0A091E2S0_FUKDA
LinkDB: A0A091E2S0_FUKDA
Original site: A0A091E2S0_FUKDA 
ID   A0A091E2S0_FUKDA        Unreviewed;       882 AA.
AC   A0A091E2S0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   20-JUN-2018, entry version 18.
DE   SubName: Full=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 {ECO:0000313|EMBL:KFO37003.1};
GN   ORFNames=H920_01650 {ECO:0000313|EMBL:KFO37003.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO37003.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO37003.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO37003.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN121161; KFO37003.1; -; Genomic_DNA.
DR   RefSeq; XP_019060637.1; XM_019205092.1.
DR   Ensembl; ENSFDAT00000003020; ENSFDAP00000014278; ENSFDAG00000001412.
DR   GeneID; 104850265; -.
DR   CTD; 8509; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0019213; F:deacetylase activity; IEA:Ensembl.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0002002; P:regulation of angiotensin levels in blood; IEA:Ensembl.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Transferase {ECO:0000313|EMBL:KFO37003.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     20     38       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    513       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      603    851       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   882 AA;  100894 MW;  EABB56835CA7EAC9 CRC64;
     MLQLWKVVCP ARQQELHRLI LLLIAFSLGS MGFLAYYVST SPKAKEPLPL PLDCSSSGAA
     GPGPARPPVP PRPPRPPETA RTEPVVLVFV ESAYSQLGQE IVALLESSRF RYSTELAPGR
     GDMPTLTDRT RGRYVLVIYE NLLKYVNLDA WSRELLDRYC VEYGVGIIGF FRAHEHSLLS
     AQLKGFPLFL HSNLGLRDYQ VNPSAPLLHL TRPSRLEPGP LPGDDWTIFQ SNHSTYEPVL
     LANLRPAEPP VPGPVPRRAR LPTVVQDLGL HDGIQRVLFG HGLSFWLHKL VFIDAVAYLT
     GKRLCLDLDR YILVDIDDIF VGKEGTRMKV ADVEALLTTQ NKLRTLVPNF TFNLGFSGKF
     YHTGTEEEDA GDDMLLKHRR EFWWFPHMWS HMQPHLFHNR SVLADQMRLN KQFALEHGIP
     TDLGYAVAPH HSGVYPIHTQ LYEAWKSVWG IQVTSTEEYP HLRPARYRRG FIHNGIMVLP
     RQTCGLFTHT IFYNEYPGGS RELDRSIRGG ELFLTVLLNP ISIFMTHLSN YGNDRLGLYT
     FESLVRFLQC WTQLRLQTLP PVPLARKYFE LFPQERSPLW QNPCDDKRHK DIWSKEKTCD
     RLPKFLIVGP QKTGTTAIHF FLSLHPAVTS SFPSPSTFEE IQFFNGPNYH KGIDWYMDFF
     PVPSNASTDF LFEKSATYFD SEVVPRRGAA LLPRAKIITV LTNPADRAYS WYQHQRAHGD
     PVALNYTFYQ VISASSQAPL VLRSLQNRCL VPGYYSTHLQ RWLMYYPSGQ LLIVDGQELR
     ANPAASMENI QKFLGITPFL NYTRTLRFDE DKGFWCQGLE GGKTRCLGKS KGRRYPDMDT
     ESRLFLTDFF RNHNLELSKL LSRLGQPVPS WLREELQNSS LG
//
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