ID   A0A091E6B0_FUKDA        Unreviewed;      1398 AA.
AC   A0A091E6B0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=5-oxoprolinase {ECO:0000313|EMBL:KFO30641.1};
GN   ORFNames=H920_08019 {ECO:0000313|EMBL:KFO30641.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30641.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO30641.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO30641.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; KN122397; KFO30641.1; -; Genomic_DNA.
DR   STRING; 885580.ENSFDAP00000020043; -.
DR   eggNOG; KOG1939; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   InterPro; IPR029385; Speriolin_N.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
DR   Pfam; PF15058; Speriolin_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1398
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001872531"
FT   DOMAIN          23..71
FT                   /note="Speriolin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15058"
FT   DOMAIN          120..321
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          341..640
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          655..819
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          844..1366
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   COILED          29..59
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1398 AA;  149682 MW;  450A3ACD7DD90AC0 CRC64;
     MAGSAIPGYL PAASLLQALL LGMSLLSSYE GLRQEIQRLA QENEELRQLV QLIQENQELK
     LVLRSRGSSL GFLAEVTASP RMLRRRTIKF KDAERGLPVE GPLLGASPTV MGNPEGHFHF
     AIDRGGTFTD VFAQCPGGRV RVLKLLSEDP ANYADAPTEG IRRILEQEGG ILLPRDRPLD
     TSRIASIRMG TTVATNALLE RQGERVALLV TRGFRHLLHI GTQARSDLFD LAVSMPEMLY
     EEVLEVEERV VLYRSEPGAG TPVKGRTGDL LEVQQPVDLG SLRGKLEGLL SRGIRSLAVV
     LMHSYTWAQH EQQVGTLARE LGFTHVSLSS ETMPMVRIVP RGHTACADAY LTPTIQRYIQ
     GFCRGFQGQL KDVQVLFMRS DGGLAPMDAF TGSRAVLSGP AGGVVGYSAT TYQLEGGQPV
     IGFDMGGTST DVSRYAGQFE HIFEASTAGV TLQAPQLDIN TVAAGGGSRL FFRSGLFVVG
     PESAGAHPGP ACYRKGGPLT VTDANLVLGR LLPASFPCIF GPGEDQPLSH EASRKALEAV
     ATEVNSFLTT GPCPASPLSL EEVAMGFVRV ANEAMCRPIR ALTQARGHDP SAHVLACFGG
     AGGQHACAIA RALGMDAVHI HRHSGLLSAL GLALADVVHE AQEPCSLPYA PETFVQLDQR
     LSHLEEQCVD TLLAQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPATA HSPQAGDFGA
     AFVERYMREF GFVIPERPVV VDNVRVRGTG RSGLHLEDTA KAQTGPPRLD KVTQCYFEGG
     YQETPVYLLG ELSYGHQLQG PCLIIDNNST ILVEPGCQAE VIETGDIRIS VGAEAPSTVG
     TKLDPIQLSI FSHRFMSIAE QMGRILQRTA ISTNIKERLD FSCALFGPDG GLVSNAPHIP
     VHLGAMQETV QFQIKHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW PGQTQPVFYV
     ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA LRAPGKIPGC
     SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ AYMGHIQANA ELAVRDMLRA
     FGTSRQAQGL PLEVSAEDHM DDGSPIHLRV QINLTQGSAV FDFSGTGPEV FGNLNAPRAI
     TLSALIYCLR CLVGHDIPLN QGCLAPVRVV IPRGSILDPS PEAAVVGGNV LTSQRVVDVI
     LGAFGACAAS QGCMNNVTLG NAHMGYYETV AGGAGAGPGW HGRSGVHSHM TNTRITDPEI
     LESRYPVILR RFELRPDSGG QGHFRGGDGV VRELLFREEA LLSVLTERRA FRPYGLCGGE
     PGASGLNLLI RKDGRIVNLG GKTSVTVYPG DVFCLHTPGG GGYGNPEDPA PPPCSAPQFP
     AFPERGSVYE YRRAQETV
//