ID A0A091E865_CORBR Unreviewed; 366 AA.
AC A0A091E865;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
DE Flags: Fragment;
GN ORFNames=N302_13464 {ECO:0000313|EMBL:KFO54258.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO54258.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO54258.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO54258.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KK718105; KFO54258.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091E865; -.
DR STRING; 85066.A0A091E865; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19394; TGF_beta_GDF10; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 254..366
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 153..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO54258.1"
FT NON_TER 366
FT /evidence="ECO:0000313|EMBL:KFO54258.1"
SQ SEQUENCE 366 AA; 41853 MW; 0A3DE66A0EAD1524 CRC64;
EFLAQKPLYC FNLTSMQDSE MILAATFHFY ADKRPRHREV FCKRSKNSSC RLLHLPPALR
LNLVFQSLHQ NSAYGLVKGN ITVLLQRRGA WHAKDISHIV KESKRAGELI LCAELDSGEK
HQGFPEQVAS HLPYILVYAN DLAISEPNSV AGTLQRYDPF PPNDGDPNLS PNASTDTRVR
RDTYLASSIQ NNELPEVDYN NNKYNKHDIW ENAYRSLKPK ASRKDRRRKG QENTETLKTS
QVLNFDEKTM KKARRKQWNE PRICSRRYMK VDFADIGWNE WIISPKSFDA YYCAGACEFP
MPKIVRPSNH ATIQSIVKAV GIIPGIPEPC CVPDKMSSLS VLFLDENKNV VLKVYPNMSV
ETCACR
//
