ID A0A091EC11_FUKDA Unreviewed; 708 AA.
AC A0A091EC11;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=T-cell activation Rho GTPase-activating protein {ECO:0000313|EMBL:KFO32836.1};
GN ORFNames=H920_05779 {ECO:0000313|EMBL:KFO32836.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32836.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO32836.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO32836.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN122124; KFO32836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091EC11; -.
DR STRING; 885580.ENSFDAP00000005649; -.
DR eggNOG; KOG4724; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 71..260
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 276..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 78274 MW; 57192B2240F9EFD4 CRC64;
METLVKCQSE GDIKEHPLLA SCESKDSICQ LIEVKKRKTG RPWPFLTRKL SPASDFSEAL
EPELKVPLFD QPLSAICTED GTLPRPIQDI LAILCLKGPS TEGIFRKAAS EKARKELKEE
LNCRDRVDLE RLPVHLLAVV LKDFLRSIPL KLLSCDLFEE WMGALEKQDE EDRIEALKQV
VGQLPQPNIL LLKHLVSVLH LISKNAEVNK MDSSNLAICI GPNMLTLEND QNLSFEAQKD
LNNKVKTLVE FLIDNCFEIF GENIPAHSNT HIVSDDSLEH TDSSDVSTLQ NDSAYDSNDP
DVEPTSAHHS PSRQPQVTIP VAAGLDNKER QDTCELSWQP IVSTVARLKS SLSQRADRRF
SEPSRPPPQE CESRMTNQKL TKSEDNFTMA QAGSCFENEK AGDPFPEEVF SAVEGKSKRP
MDLRIKNLTQ GLALPQGVVP KALSSGSPDG SSDCSPINSP SCPKRNFFTR HQSFTTKTDK
SKSNREIKKH SMSFSFASHK KVLPIASSLG SGKSKDLTRD QVKKSLRKES QLAGRIVQEN
GSDLHSQTAL GFGLPSRAFS GDDVFQQVEG MSPGSPPSYE EAIQCQALGL GACSGQTVGS
MRARMLSQDS TLSSLLPSYH RGDSRSSCSV ETLSGHRLSS MAEYWRQSRT VSDSVEAQGH
VTVPGRPGLR LRTMSESLQK DKQDCLGQRC SQPIFEADQL HCVKESYI
//
