ID A0A091EEU1_CORBR Unreviewed; 550 AA.
AC A0A091EEU1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 32.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 2 {ECO:0000313|EMBL:KFO54954.1};
DE Flags: Fragment;
GN ORFNames=N302_14689 {ECO:0000313|EMBL:KFO54954.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO54954.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO54954.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO54954.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KK718210; KFO54954.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091EEU1; -.
DR STRING; 85066.A0A091EEU1; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15741; FYVE_FGD1_2_4; 1.
DR CDD; cd13386; PH1_FGD2; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR037797; FGD2_PH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF82; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 3..191
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 220..319
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 357..417
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 443..540
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO54954.1"
FT NON_TER 550
FT /evidence="ECO:0000313|EMBL:KFO54954.1"
SQ SEQUENCE 550 AA; 63853 MW; 9BF0C72C943A5E90 CRC64;
EPEEKKIALE LLETEQAYVN RLHLLDQVFY KELMKEAKTG KTIPEEVVKM IFSNISSIYQ
FHAEFFLPEL RKRMEDWNRN PRIGDVIQKL APFLKMYGEY VKNFDKAVEL ITAWSEKSPP
FQELIADIQK RKVCANLTLQ HHMLEPVQRI PRYELLLKDY VRKLPPQSPD RGDAEKALEM
IFMVAKHSNA AIAEMERLQN LWVVYQRLGL EDDIVDPSNE LIKEGPIQKI STRNNSTSEK
YLFLFNNMLL YCVPKVIQVG AEFQVHLRMD VEGMKVRELK DIEFPHTFLV SGKQRTLELQ
ARSGEEMNAW IKAFQDAIDR KEKRSETFKT AVHGLETDTP AVKTEELGRR APQWVRDNLV
TMCMRCKEPF NAITRRRHHC RACGYVVCAR CSDYKAELQY DGNRPNRVCQ ECYIFLTGHT
VLEDREGKHK GILEKGAAEV SSRSLLCSSL QLLDKNGKGS TRGWFVIPQD DPLVLYIYAA
PQDVRAHTSI PLLGYQVRDM PQSESRHLFQ LAQSRQVFTF VADTEELKRR WMRAMARSAA
GITHPEEEEE
//
