ID A0A091EFT4_FUKDA Unreviewed; 1755 AA.
AC A0A091EFT4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Signal-induced proliferation-associated 1-like protein 2 {ECO:0000313|EMBL:KFO34231.1};
GN ORFNames=H920_04360 {ECO:0000313|EMBL:KFO34231.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34231.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34231.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34231.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN122008; KFO34231.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000023110; -.
DR eggNOG; KOG3686; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.1120.160; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 648..865
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 1003..1079
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1691..1739
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1755 AA; 193524 MW; 09CD910097806D1E CRC64;
MSDPRQSQAE KHKLGRASSK FMDPSRIMQS DDYFARKFKA INGNMGPTAS LNASNPSESG
GGGGGPANGT PPVPKMGVRA RVSEWPPKKD FSKEPTCKTL WESRSQTSYD SVTSILQNGQ
SDQGDSQQEE QLDLDFVEAK YTIGDIFVHS PQRGLHPIRQ RSNSDVTISD IDAEDVLDQR
AVNPNTGAAL HREYGSTSSI DRQGLSGENF FAMLRGYRVE NYDPKAVGSF AFPEFLPCDP
AISPSLRAAA QISRGEIVRI SGLDYMDSAL LMGRDRDKPF KRRLKSESVE TSLFRKLRTV
KSEHENFKFT SDLEEGCLDR GIRPWSCQRC FAHYDVQSIL FNINEAMATR ANVGKRKNIT
TGASAASQTQ VPTGQAGGCE SPLGSKEDLN SKENLDADEG DGKSNDLVLS CSHFRNEIGG
EGDRRIALSR ASSGSFSSGE SCSFESSLSS HCTNAGVSVL EVPRESQPIH REKVKRYIIE
HVDLGAYYYR KFFYGKEHQN YFGIDENLGP VAVSIRREKV EDAKEKEGSQ FNYRVAFRTS
ELTTLRGAIL EDAVPSTARH GTTRGLPLKE VLEYVIPELS IQCLRQASSS PKLTTLRGAI
LEDAVPSTAR HGTTRGLPLK EVLEYVIPEL SIQCLRQASS SPKVPEQLLK LDEQGLSFQH
KIGILYCKAG QSTEEEMYNN ETAGPAFDEF LDLLGQRVRL KGFSKYRAQL DNKTDSTGTH
SLYTTYKDYE LMFHVSTLLP YMPNNRQQLL RKRHIGNDIV TVVFQEPGAL PFTPRSIRSH
FQHVFVIVRV HSPCTENVCY SVGVSRSKDV PPFGPPIPKG VTFPKSAVFR DFLLAKVINA
ENAAHKSEKF RAMATRTRQE YLKDLAENFV TTATVDTSAK FSFITLGAKK KERVKPRKDA
HLFSIGAIMW HMVARDFGQS ADIECLLGIS NEFIMLIEKD SKNVVFNCSC RDVIGWTSGL
MSIKVFYERG ECILLSSVDN CTEDIREIVQ RLVIVTRGCE TVEMTLRRNG LGQLGFHVNF
EGIVADVEPF GFAWKAGLRQ GSRLVEICKV AVATLTHEQM IDLLRTSVTV KVVIIQPHDD
GSPRRGCSEL CRVPLVEYKL DSEGAPCEYK TPFRRNNAWH RVPTPALQPL SRASPVPGTP
DRLQCQQLLQ QAQAAIPRST SFDRKLPDGT RSSPSNQSSS SDPGPGGSGP WRPQVGYDGC
QSPLLLEHQG PGPLDCDGAR EHEDAMEGSR VTESKWHGPP SKVLNTYKER ALQKDGSCKD
SPNKLSHIGD KSCSSHSSSN TLSSNTSSNS DDKHFGSGDL MDPELLGLTY IKGASTDSGI
DTAPCMPATI LGPVHLVGSR SLIHSRSEQW ADGTEVSGTD DEPAKMYAVH SYTSAISTSG
AADGSVGDLS EVSSHSSGSH HSGSPSAHCS KSSGSLDTSK VYIVSHSSSQ QVPGSKSYHR
QGATNKYVIG WKKSEDSPPP EEPEVTECTR MYSEMDVLAT AAQCQTAVGD AGSETQHVLS
KEDFLKLMLP DSPLVEEGRR KFSFYGNLSP RRSLYRTLSD ESVCSTRRGS SYGSSRSSIL
DQALPNDILF STTPPYHSTL PPRTHPAPSM GSLRNEFWFS DGSLSDKSKC ADPGLMPLPD
TAMGLDWSHL VDAARAFEDQ RVASFCTLTD LQHRQDLEGA LELPMCIDPG SGKEFMDASG
ERSPSTLTGK VNQLELILRQ LQTDLRKEKQ DKAVLQAEVQ HLRQDNRRLQ EESQTAAAQL
RRFTEWFFNT VDKKS
//
