ID A0A091EI08_CORBR Unreviewed; 684 AA.
AC A0A091EI08;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3 {ECO:0000256|ARBA:ARBA00016514};
DE AltName: Full=Pre-mRNA-splicing factor 3 {ECO:0000256|ARBA:ARBA00032955};
GN ORFNames=N302_10874 {ECO:0000313|EMBL:KFO56029.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO56029.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO56029.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO56029.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-
CC U5 tri-snRNP complex that is involved in spliceosome assembly, and as
CC component of the precatalytic spliceosome (spliceosome B complex).
CC {ECO:0000256|ARBA:ARBA00035603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK718428; KFO56029.1; -; Genomic_DNA.
DR RefSeq; XP_008627839.1; XM_008629617.2.
DR AlphaFoldDB; A0A091EI08; -.
DR STRING; 85066.A0A091EI08; -.
DR GeneID; 103612047; -.
DR KEGG; cbrc:103612047; -.
DR CTD; 9129; -.
DR OrthoDB; 5489218at2759; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR013881; Pre-mRNA_splic_Prp3_dom.
DR InterPro; IPR027104; Prp3.
DR InterPro; IPR010541; Prp3_C.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR036483; PWI_dom_sf.
DR PANTHER; PTHR14212; U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED; 1.
DR PANTHER; PTHR14212:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3; 1.
DR Pfam; PF08572; PRP3; 1.
DR Pfam; PF06544; Prp3_C; 1.
DR Pfam; PF01480; PWI; 1.
DR SMART; SM00311; PWI; 1.
DR SUPFAM; SSF101233; PWI domain; 1.
DR PROSITE; PS51025; PWI; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Ribonucleoprotein {ECO:0000313|EMBL:KFO56029.1};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 1..87
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 73..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 77384 MW; E9E63178410EECAD CRC64;
MSLSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL
RFVDKLFEAV EEGRSSRHSK SNSDRTRKRE LKDVFGDDSE VSKESSGVKK RRIPRFEEVE
DEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KISSSSQSER
LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI
APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK
PSEDMESNTY FDPRVSITPA QRQKRTFKFH EKGKFEKIAQ RLRTKAQLEK LQAEISQAAR
KTGIHTSTKL ALITPKKELK EGEIPEIEWW DSYIIPNGLD LKGGAISKKD EYFGITNLVE
HPAQLNPPVD SDTPVTLGVY LTKKEQKKLR RQTRREAQKE LQEKVRLGLM PPPEPKVRIS
NLMRVLGTEA VQDPTKVEAH VRAQMAKRQK AHEEANAARK LTAEQRKAKK VKKLKEDVSQ
GVHIAVYRVR NLSNPAKKFK IEANAGQLYL TGVVVLHKDV NVVVVEGGPK AQKKFKRLML
HRIKWDEQTS NTKGEDDDES DEESVKKTNK CSLVWEGTAK DRSFGEMKFK QCPTENMARE
HFKKHSAEHY WDLALSESVL ESTD
//
