ID   A0A091EJF9_CORBR        Unreviewed;       256 AA.
AC   A0A091EJF9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Putative oxidoreductase ZK1290.5 {ECO:0000313|EMBL:KFO56524.1};
DE   Flags: Fragment;
GN   ORFNames=N302_00603 {ECO:0000313|EMBL:KFO56524.1};
OS   Corvus brachyrhynchos (American crow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC   Corvus.
OX   NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO56524.1, ECO:0000313|Proteomes:UP000052976};
RN   [1] {ECO:0000313|EMBL:KFO56524.1, ECO:0000313|Proteomes:UP000052976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO56524.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC       {ECO:0000256|ARBA:ARBA00007905}.
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DR   EMBL; KK718445; KFO56524.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091EJF9; -.
DR   STRING; 85066.A0A091EJF9; -.
DR   Proteomes; UP000052976; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19135; AKR_CeZK1290-like; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF10; ZGC:110366; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000052976}.
FT   DOMAIN          11..240
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        30
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         88
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            55
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO56524.1"
FT   NON_TER         256
FT                   /evidence="ECO:0000313|EMBL:KFO56524.1"
SQ   SEQUENCE   256 AA;  29493 MW;  897C18FB9E6E6FB9 CRC64;
     TSHQGGYSHT AVVHALQKCG IRHIDTAKRY GCESLLQRAI RESAVKREDL WITTKLWHSD
     CGYESTKKAC LESCERLGVE YLDLYLIHWP DAQVPGKSNR EVRAETWRAM EELYEKGLCK
     SIGVSNFLIS HLEQLKEDCV ITPHVNQVEY HPFQRPQELV DYCRRRDIVF EGYCPLAKGE
     ALTHPTIIQL AKKYGRTPAQ ICIRWSIQNG IVTIPKSTKV ERIEENCKVR FAEDDVEILN
     GMHDGRHVSW DPSFIV
//